Dermatology Clinical Trials Unit, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Rowan-Virtua School of Osteopathic Medicine, Stratford, New Jersey, USA.
Skin Res Technol. 2024 Sep;30(9):e70041. doi: 10.1111/srt.70041.
Psoriasis is an immune-mediated inflammatory skin disease. First-line topical treatments include steroids, calcineurin inhibitors, vitamin D analogs, and anthralin. Recently, novel topical therapeutics like tapinarof and roflumilast have emerged with unique anti-inflammatory mechanisms and promising efficacy profiles.
This review utilized PubMed, SCOPUS, and Web of Science databases to identify recent studies on tapinarof and roflumilast. Criteria focused on efficacy, safety profiles, and therapeutic roles in psoriasis treatment.
Four primary literature articles were identified for tapinarof and five for roflumilast. Both drugs demonstrated strong efficacy with minimal adverse events in treating mild-to-moderate plaque psoriasis. Tapinarof showed more frequent but mild adverse effects, while roflumilast had less frequent but more severe side effects.
Tapinarof and roflumilast offer once-daily dosing and successful treatment in restricted areas, potentially enhancing patient adherence. Cost remains a limiting factor, necessitating future comparative studies to evaluate the efficacy, safety, and cost-effectiveness between the two drugs.
Tapinarof and roflumilast present promising topical treatments for psoriasis, showing efficacy and manageable safety profiles. Further research is crucial to fully elucidate their comparative benefits and drawbacks in clinical practice.
银屑病是一种免疫介导的炎症性皮肤病。一线局部治疗包括皮质类固醇、钙调磷酸酶抑制剂、维生素 D 类似物和蒽林。最近，新型局部治疗药物如他卡西醇和罗氟司特具有独特的抗炎机制和有前景的疗效特征。
本综述利用 PubMed、SCOPUS 和 Web of Science 数据库，确定了关于他卡西醇和罗氟司特的最新研究。标准侧重于疗效、安全性概况以及在银屑病治疗中的治疗作用。
确定了 4 篇关于他卡西醇的主要文献和 5 篇关于罗氟司特的文献。这两种药物在治疗轻度至中度斑块状银屑病方面均显示出较强的疗效，且不良反应最小。他卡西醇显示出更频繁但较轻的不良反应，而罗氟司特则具有较少但更严重的副作用。
他卡西醇和罗氟司特提供每日一次的给药方案，并且可以在受限区域成功治疗，这可能会提高患者的依从性。成本仍然是一个限制因素，因此需要未来进行比较研究，以评估这两种药物在疗效、安全性和成本效益方面的差异。
他卡西醇和罗氟司特为银屑病提供了有前景的局部治疗方法，显示出疗效和可管理的安全性特征。进一步的研究对于充分阐明它们在临床实践中的比较优势和劣势至关重要。
