Opt Lett. 2024 Sep 1;49(17):4843-4846. doi: 10.1364/OL.532993.
Photo-sono therapy (PST) is an innovative anti-vascular approach based on cavitation-induced spallation. Currently, passive cavitation detection (PCD) is the prevalent technique for cavitation monitoring during treatment. However, the limitations of PCD are the lack of spatial information of bubbles and the difficulty of integration with the PST system. To address this, we proposed a new, to the best of our knowledge, cavitation mapping method that integrates Doppler optical coherence tomography (OCT) with PST to visualize bubble dynamics in real time. The feasibility of the proposed system has been confirmed through experiments on vascular-mimicking phantoms and in vivo rabbit ear vessels, and the results are compared to high-speed camera observations and PCD data. The findings demonstrate that Doppler OCT effectively maps cavitation in real time and holds promise for guiding PST treatments and other cavitation-related clinical applications.
光声疗法（PST）是一种基于空化诱导层裂的创新的抗血管方法。目前，被动空化检测（PCD）是治疗过程中空化监测的常用技术。然而，PCD 的局限性在于缺乏气泡的空间信息和与 PST 系统集成的困难。为了解决这个问题，我们提出了一种新的空化绘图方法，该方法将多普勒光相干断层扫描（OCT）与 PST 结合，实时可视化气泡动力学。通过对血管模拟体模和活体兔耳血管的实验，证实了所提出系统的可行性，并将结果与高速摄像机观察和 PCD 数据进行了比较。研究结果表明，多普勒 OCT 可以有效地实时绘制空化图，有望用于指导 PST 治疗和其他与空化相关的临床应用。
