Charmduzi Forugh, Ebrahimi Hamidreza Khoshnezhad, Jafarnejad Shabahang, Gharab Saeid Gholami, Iranmanesh Saeideh, Jafarnejad Meissa, Mousaeinejad Negin
Department of Pediatrics, Aliasghar Children's Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Emergency Medicine, Aliasghar Children's Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
J Family Med Prim Care. 2024 Aug;13(8):3339-3344. doi: 10.4103/jfmpc.jfmpc_1562_23. Epub 2024 Jul 26.
Despite significant progress in supportive care and advancements in chemotherapy treatments, cancer remains a leading cause of mortality in children. The objective of this study was to assess the potential correlation between various risk factors and the consequences of patients with pediatric cancer who were admitted to the pediatric intensive care unit (PICU).
The present investigation is a retrospective cohort study that examined children with cancer who were between the ages of 1 month and 17 years and had been admitted to the PICU. Demographic and clinical information of all patients, including such as the age, type of cancer, sex, BMI, history of specific disease, PICU admission time, disease condition on PICU admission, patient's status at PICU admission, and number of organ failures, were extracted from each patient file.
The number of pediatric oncology patients admitted to the PICU was 127. The highest mortality rate was observed among children with heart problems (75%), followed by CNS involvement (54.2%) and sepsis (42.9%). The study found that various factors had a significant effect on the outcomes of patients who were admitted to the PICU, including but not limited to the primary type of malignancy, disease status, indications for hospital admission, patient's condition, inpatients' length of stay (LOS), tumor type, and the extent of organ failure at the time of admission to the PICU.
Despite recent advancements in healthcare, the prognosis of patients admitted to the PICU in underdeveloped areas remains suboptimal in comparison to those in developed regions. Poor outcomes were found to be significantly associated with various factors, including the primary type of malignancy, disease status, the reason for admission to the PICU, patient's condition, LOS, tumor type, and the extent of organ failure, especially in cases involving hematological malignancies.
尽管在支持治疗方面取得了重大进展，化疗治疗也有所进步，但癌症仍然是儿童死亡的主要原因。本研究的目的是评估各种风险因素与入住儿科重症监护病房（PICU）的儿科癌症患者的后果之间的潜在相关性。
本调查是一项回顾性队列研究，研究对象为年龄在1个月至17岁之间且入住PICU的癌症患儿。从每个患者档案中提取所有患者的人口统计学和临床信息，包括年龄、癌症类型、性别、BMI、特定疾病史、PICU入院时间、PICU入院时的疾病状况、PICU入院时患者的状态以及器官衰竭数量。
入住PICU的儿科肿瘤患者有127例。心脏问题患儿的死亡率最高（75%），其次是中枢神经系统受累（54.2%）和败血症（42.9%）。研究发现，各种因素对入住PICU的患者的预后有显著影响，包括但不限于恶性肿瘤的主要类型、疾病状态、入院指征、患者状况、住院时间（LOS）、肿瘤类型以及入住PICU时的器官衰竭程度。
尽管近期医疗有所进步，但与发达地区相比，欠发达地区入住PICU的患者预后仍然不理想。发现不良预后与各种因素显著相关，包括恶性肿瘤的主要类型、疾病状态、入住PICU的原因、患者状况、住院时间、肿瘤类型以及器官衰竭程度，尤其是在涉及血液系统恶性肿瘤的病例中。
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