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通过扩张性病变确诊的结核性小脑炎:一例报告

Tubercular cerebellitis, identified through an expansive process: A case report.

作者信息

Maasaoui Kaoutar, El Bouardi Nizar, Hamdaoui Amina, Akammar Amal, Haloua Meryem, Alami Badreeddine, Lamrani Moulay Youssef Alaoui, Boubbou Meryem, Maaroufi Mustapha

机构信息

Department of Radiology and Interventional Imaging, CHU Hassan II Fez, Sidi Mohammed Ben Abdellah University, Fez, Morocco.

出版信息

Radiol Case Rep. 2024 Aug 10;19(11):4788-4793. doi: 10.1016/j.radcr.2024.07.110. eCollection 2024 Nov.

Abstract

Central nervous system (CNS) tuberculosis is a postprimary form of tuberculosis with high mortality and morbidity rates, even with early diagnosis and treatment. Focal tuberculous cerebritis is extremely rare, typically occurring in patients without AIDS, and often associated with tuberculous meningitis. In endemic regions, it should be a primary consideration when encountering cerebral anomalies suggestive of granulomatous conditions. Its meningeal pseudo-tumor form poses a significant diagnostic challenge. We present the case of a 26-year-old man who arrived at the emergency room with cerebellar and pyramidal syndrome. Cerebral magnetic resonance imaging (MRI) revealed an expansive lesion in the right hemicerebellum with glove-finger edema and leptomeningeal thickening. Given the MRI findings and associated lung involvement, the diagnosis of tuberculosis was strongly suggested in our epidemiological context. Due to contraindications for lumbar puncture, high surgical risk, and strong clinical and radiological suspicion, antituberculous treatment was initiated in collaboration with neurologists and infectious disease specialists. The clinical and radiologic manifestations of CNS tuberculosis can mimic other infectious and noninfectious neurological conditions, as seen in our patient. Thus, familiarity with the imaging presentations of CNS tuberculosis among infectious disease specialists and radiologists is crucial for prompt and accurate diagnosis.

摘要

中枢神经系统(CNS)结核是一种继发性结核,即使早期诊断和治疗,其死亡率和发病率仍很高。局灶性结核性脑炎极为罕见,通常发生在无艾滋病的患者中,且常与结核性脑膜炎相关。在流行地区,遇到提示肉芽肿性疾病的脑部异常时,应将其作为首要考虑因素。其脑膜假瘤形式构成了重大的诊断挑战。我们报告一例26岁男性患者,他因小脑和锥体综合征来到急诊室。脑部磁共振成像(MRI)显示右半小脑有一个膨胀性病变,伴有手套状指水肿和软脑膜增厚。鉴于MRI表现及相关肺部受累情况,在我们所处的流行病学背景下,强烈提示为结核。由于腰椎穿刺有禁忌证、手术风险高,且临床和影像学高度怀疑,遂与神经科医生和传染病专家合作开始抗结核治疗。正如我们的患者所示,CNS结核的临床和影像学表现可模仿其他感染性和非感染性神经系统疾病。因此,传染病专家和放射科医生熟悉CNS结核的影像学表现对于及时准确的诊断至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b80/11366934/e28c50323276/gr1.jpg

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