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人乳头瘤病毒疫苗接种及相关伦理问题综述

A Review of Human Papillomavirus Vaccination and Associated Ethical Concerns.

作者信息

Fu Eric, Erdemir Ozdemir, Pathan Khalil, Brophy Meaghan, Pettit Aidan

机构信息

University of Colorado School of Medicine, Aurora, CO, USA.

Drexel University College of Medicine, Philadelphia, PA, USA.

出版信息

Infect Chemother. 2024 Dec;56(4):432-439. doi: 10.3947/ic.2024.0070. Epub 2024 Aug 8.

Abstract

Since its Fast-Track approval by the Federal Drug Administration, the human papillomavirus (HPV) vaccine has been marked by controversies. Unconfirmed reports of adverse events in both Japan and Denmark led to suspensions of national vaccination programs, which setback the fight against cervical cancer and associated mortality and morbidity. Despite follow-up studies of vaccine adverse reports, additional randomized control trials, and review reports from both the World Health Organization and the European Commission, there is still a great deal of hesitancy around the vaccine. While all three version of the HPV vaccine have been shown to be efficacious and safe, additional ethical dilemmas deserve to be considered as well.

摘要

自被美国食品药品监督管理局快速批准以来,人乳头瘤病毒(HPV)疫苗一直备受争议。日本和丹麦未经证实的不良事件报告导致两国暂停国家疫苗接种计划,这阻碍了抗击宫颈癌以及相关死亡率和发病率的斗争。尽管对疫苗不良报告进行了后续研究、开展了更多随机对照试验,且世界卫生组织和欧盟委员会也发布了审查报告,但围绕该疫苗仍存在诸多犹豫情绪。虽然所有三种版本的HPV疫苗都已被证明有效且安全,但其他伦理困境也值得考虑。

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