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癌症治疗相关心脏功能障碍的管理:基于病例的综述。

Management of Cancer Therapy-Related Cardiac Dysfunction: A Case-Based Review.

机构信息

Division of Cardiology, Department of Medicine, Zuckerberg San Francisco General Hospital; Division of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, California.

Division of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, California.

出版信息

Am J Cardiol. 2024 Nov 15;231:20-31. doi: 10.1016/j.amjcard.2024.08.029. Epub 2024 Sep 2.

Abstract

With an ever-expanding repertoire of cancer therapies, cardiologists increasingly encounter patients with cancer therapy-related cardiac dysfunction. This can range from asymptomatic mild left ventricular dysfunction to severe symptomatic congestive heart failure. A multidisciplinary approach involving oncologists and cardiologists is needed in the management of these patients. This case-based review provides a practical guide for clinicians regarding the diagnosis and management of cancer therapy-related cardiac dysfunction associated with commonly used cancer treatments: anthracyclines, human epidermal receptor 2-targeted therapies, and immune checkpoint inhibitors.

摘要

随着癌症治疗方法的不断扩展,心脏病专家越来越多地遇到与癌症治疗相关的心脏功能障碍的患者。这种情况可以从无症状的轻度左心室功能障碍到严重的有症状的充血性心力衰竭。在这些患者的管理中,需要涉及肿瘤学家和心脏病专家的多学科方法。本案例综述为临床医生提供了与常用癌症治疗方法(蒽环类药物、人表皮生长因子受体 2 靶向治疗和免疫检查点抑制剂)相关的癌症治疗相关心脏功能障碍的诊断和管理的实用指南。

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