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病例报告:系统性红斑狼疮(SLE)并发脑血管炎的 18 岁女性病例报告。

Case Report: A Case Report on an 18-Year-Old Female with Cerebral Vasculitis in Systemic Lupus Erythematosus (SLE).

机构信息

Department of Radio-Diagnosis,, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, 442001, India.

出版信息

F1000Res. 2024 Jun 11;13:614. doi: 10.12688/f1000research.152704.1. eCollection 2024.

Abstract

Cerebral vasculitis is a rare but severe complication of Systemic Lupus Erythematosus (SLE), presenting significant challenges in management due to its potential for devastating neurological consequences and poor prognosis. We present a case of an 18-year-old female with known SLE who presented with seizures, declining cognitive function, and unresponsiveness. Neurological examination, laboratory investigations, and radiological imaging supported the diagnosis of cerebral vasculitis secondary to SLE. Despite aggressive immunosuppressive therapy, the patient's neurological status continued to deteriorate, leading to respiratory failure and multiorgan dysfunction. Ultimately, the patient succumbed to multiorgan failure attributed to severe CNS vasculitis and its complications. This case underscores the importance of early recognition and aggressive management of cerebral vasculitis in SLE while highlighting the need for further research into more effective therapeutic strategies to improve patient outcomes.

摘要

脑血管炎是系统性红斑狼疮(SLE)的一种罕见但严重的并发症,由于其可能导致毁灭性的神经后果和预后不良,在管理方面带来了重大挑战。我们报告了一例 18 岁女性 SLE 患者,其表现为癫痫发作、认知功能下降和无反应。神经科检查、实验室检查和影像学检查支持 SLE 继发的脑血管炎的诊断。尽管进行了积极的免疫抑制治疗,但患者的神经状态持续恶化,导致呼吸衰竭和多器官功能障碍。最终,患者因严重中枢神经系统血管炎及其并发症导致多器官衰竭而死亡。该病例强调了早期识别和积极治疗 SLE 中的脑血管炎的重要性,同时突出了需要进一步研究更有效的治疗策略以改善患者结局的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df6f/11372350/14536db5378a/f1000research-13-167497-g0000.jpg

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