Chen Jie, Xu Ruiting, Meng Lingjie, Yan Fei, Wang Lingtao, Xu Yi, Zhang Qiuyang, Zhai Wanli, Pan Changjiang
Faculty of Mechanical and Material Engineering, Jiangsu Provincial Engineering Research Center for Biomaterials and Advanced Medical Devices, Huaiyin Institute of Technology, Huai'an 223003, China.
The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223003, China.
Colloids Surf B Biointerfaces. 2025 Jan;245:114204. doi: 10.1016/j.colsurfb.2024.114204. Epub 2024 Sep 3.
The fast biodegradation and poor biocompatibility of Mg alloys in physiological environments are still the main problems restricting their application in cardiovascular stents. In this study, the hydrogel coatings (SBMA-AAM) with different proportions of methacryloyl ethyl sulfobetaine (SBMA) and acrylamide (AAM) were built on the surface of AZ31B magnesium alloy through ultraviolet (UV) polymerization. The corrosion degradation behavior, hemocompatibility, and endothelial cell (EC) growth performance of the samples were studied in detail. The findings revealed that the uniform and dense SBMA-AAM coatings could significantly enhance the corrosion resistance. In addition, the hydrogel coatings showed excellent hydrophilicity, which increased the albumin adsorption while inhibiting the fibrinogen adsorption, and thus reduced the platelet adhesion and activation and hemolysis rate, accordingly significantly enhancing their anticoagulant performance. Furthermore, SBMA-AAM hydrogel coating promoted the EC adhesion and proliferation and the vascular endothelial growth factor (VEGF) and nitric oxide (NO) secretion of ECs, which is conducive to promoting endothelialization. When the concentration ratio of SBMA and AAM was 1: 2, the modified magnesium alloy showed the best corrosion resistance and biocompatibility. Therefore, the SBMA-AAM hydrogel coating could effectively regulate the corrosion degradation performance and biocompatibility of Mg alloys, laying a foundation for the application of Mg alloys in cardiovascular stents.
镁合金在生理环境中快速的生物降解性和较差的生物相容性仍然是限制其在心血管支架中应用的主要问题。在本研究中，通过紫外（UV）聚合在AZ31B镁合金表面构建了具有不同比例甲基丙烯酰基乙基磺基甜菜碱（SBMA）和丙烯酰胺（AAM）的水凝胶涂层（SBMA-AAM）。详细研究了样品的腐蚀降解行为、血液相容性和内皮细胞（EC）生长性能。研究结果表明，均匀致密的SBMA-AAM涂层可显著提高耐腐蚀性。此外，水凝胶涂层表现出优异的亲水性，增加了白蛋白吸附，同时抑制了纤维蛋白原吸附，从而降低了血小板粘附和活化以及溶血率，相应地显著提高了它们的抗凝血性能。此外，SBMA-AAM水凝胶涂层促进了EC的粘附和增殖以及ECs的血管内皮生长因子（VEGF）和一氧化氮（NO）分泌，这有利于促进内皮化。当SBMA与AAM的浓度比为1:2时，改性镁合金表现出最佳的耐腐蚀性和生物相容性。因此，SBMA-AAM水凝胶涂层可有效调节镁合金的腐蚀降解性能和生物相容性，为镁合金在心血管支架中的应用奠定了基础。
