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孕期社会经济地位与 8 项欧洲出生队列研究中儿童的学前外显子组关联

Socioeconomic position during pregnancy and pre-school exposome in children from eight European birth cohort studies.

机构信息

Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO Piemonte, Turin, Italy.

Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO Piemonte, Turin, Italy.

出版信息

Soc Sci Med. 2024 Oct;359:117275. doi: 10.1016/j.socscimed.2024.117275. Epub 2024 Aug 31.


DOI:10.1016/j.socscimed.2024.117275
PMID:39236481
Abstract

Distribution of environmental hazards and vulnerability to their effects vary across socioeconomic groups. Our objective was to analyse the relationship between child socioeconomic position (SEP) at birth and the external exposome at pre-school age (0-4 years). This study included more than 60,000 children from eight cohorts in eleven European cities (Oslo, Copenhagen, Bristol, Bradford, Rotterdam, Nancy, Poitiers, Gipuzkoa, Sabadell, Valencia and Turin). SEP was measured through maternal education and a standardised indicator of household income. Three child exposome domains were investigated: behavioral, diet and urban environment. We fitted separate logistic regression model for each exposome variable - dichotomised using the city-specific median - on SEP (medium/low vs high) adjusting for maternal age, country of birth and parity. Analyses were carried out separately in each study-area. Low-SEP children had, consistently across study-areas, lower Odds Ratios (ORs) of breastfeeding, consumption of eggs, fish, fruit, vegetables and higher ORs of TV screen time, pet ownership, exposure to second-hand smoke, consumption of dairy, potatoes, sweet beverages, savory biscuits and crisps, fats and carbohydrates. For example, maternal education-breastfeeding OR (95% Confidence Interval (CI)) ranged from 0.18 (0.14-0.24) in Bristol to 0.73 (0.58-0.90) in Oslo. SEP was also strongly associated with the urban environment with marked between-city heterogeneity. For example, income-PM OR (95%CI) ranged from 0.69 (0.47-1.02) in Sabadell to 2.44 (2.16-2.72) in Oslo. Already at pre-school age, children with lower SEP have consistently poorer diets and behaviours, which might influence their future health and wellbeing. SEP-urban environment relationships are strongly context-dependent.

摘要

环境危害的分布和对其影响的脆弱性因社会经济群体而异。我们的目标是分析儿童出生时的社会经济地位 (SEP) 与学前年龄 (0-4 岁) 的外部暴露组之间的关系。这项研究包括来自欧洲 11 个城市的 8 个队列的 60,000 多名儿童(奥斯陆、哥本哈根、布里斯托、布拉德福德、鹿特丹、南希、普瓦捷、吉普斯夸、萨瓦德尔、瓦伦西亚和都灵)。SEP 通过母亲的教育程度和家庭收入的标准化指标来衡量。研究调查了三个儿童暴露组领域:行为、饮食和城市环境。我们为每个暴露组变量(使用城市特定中位数进行二分)拟合了单独的逻辑回归模型 - 针对 SEP(中/低与高)进行调整,包括母亲年龄、出生国和产次。分析分别在每个研究区域进行。在整个研究区域中,低 SEP 儿童的母乳喂养、食用鸡蛋、鱼类、水果、蔬菜的比例较低,而看电视时间、宠物拥有率、二手烟暴露、食用乳制品、土豆、甜饮料、咸味饼干和薯片、脂肪和碳水化合物的比例较高。例如,母亲教育-母乳喂养的比值比(95%置信区间(CI))范围从布里斯托的 0.18(0.14-0.24)到奥斯陆的 0.73(0.58-0.90)。SEP 与城市环境也密切相关,城市之间存在明显的异质性。例如,收入-PM 的比值比(95%CI)范围从萨瓦德尔的 0.69(0.47-1.02)到奥斯陆的 2.44(2.16-2.72)。早在学前年龄,社会经济地位较低的儿童的饮食和行为就一直较差,这可能会影响他们未来的健康和幸福。SEP-城市环境关系强烈依赖于背景。

相似文献

[1]
Socioeconomic position during pregnancy and pre-school exposome in children from eight European birth cohort studies.

Soc Sci Med. 2024-10

[2]
The Urban Exposome during Pregnancy and Its Socioeconomic Determinants.

Environ Health Perspect. 2018-7-17

[3]
Modelling socioeconomic position as a driver of the exposome in the first 18 months of life of the NINFEA birth cohort children.

Environ Int. 2023-3

[4]
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Environ Int. 2022-5

[5]
Human Early Life Exposome (HELIX) study: a European population-based exposome cohort.

BMJ Open. 2018-9-10

[6]
Effect of residential relocation on environmental exposures in European cohorts: An exposome-wide approach.

Environ Int. 2023-3

[7]
Social inequalities and dental caries in six-year-old children from the Netherlands.

J Dent. 2017-4-24

[8]
Socioeconomic Inequalities in the External Exposome in European Cohorts: The EXPANSE Project.

Environ Sci Technol. 2024-9-17

[9]
Socioeconomic inequalities in reproductive outcomes in the Italian NINFEA birth cohort and the Piedmont Birth Registry.

Epidemiol Prev. 2020

[10]
Development of socioeconomic inequalities in obesity among Dutch pre-school and school-aged children.

Obesity (Silver Spring). 2014-7-10

引用本文的文献

[1]
The Relationship Between Modeling, Caregiver Education, and Diverse Diet in Costa Rican Preschool Children.

Nutrients. 2025-6-24

[2]
A good move for health?: Analyzing urban exposure trajectories of residential relocation and mental health in populations in Bradford.

Environ Epidemiol. 2025-5-23

[3]
Social inequalities in childhood asthma.

World Allergy Organ J. 2024-12-3

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