Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, School of Stomatology, Henan University, Kaifeng, Henan, 475004, China; School of Clinical Medicine, Henan University, Kaifeng, Henan, 475004, China.
Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, School of Stomatology, Henan University, Kaifeng, Henan, 475004, China; Kaifeng Key Laboratory of Periodontal Tissue Engineering, School of Stomatology, Henan University, Kaifeng, Henan, 475004, China.
Chem Biol Interact. 2024 Nov 1;403:111226. doi: 10.1016/j.cbi.2024.111226. Epub 2024 Sep 3.
Hydrogen sulfide (HS), an endogenous gasotransmitter, plays a key role in several critical physiological and pathological processes in vivo, including vasodilation, anti-infection, anti-tumor, anti-inflammation, and angiogenesis. In colorectal cancer (CRC), aberrant overexpression of HS-producing enzymes has been observed. Due to the important role of HS in the proliferation, growth, and death of cancer cells, HS can serve as a potential target for cancer therapy. In this review, we thoroughly analyzed the underlying mechanism of action of HS in CRC from the following aspects: the synthesis and catabolism of HS in CRC cells and its effect on cell signal transduction pathways; the inhibition effects of exogenous HS donors with different concentrations on the growth of CRC cells and the underlying mechanism of HS in garlic and other natural products. Furthermore, we elucidate the expression characteristics of HS in CRC and construct a comprehensive HS-related signaling pathway network, which has important basic and practical significance for promoting the clinical research of HS-related drugs.
硫化氢（HS）作为一种内源性气体递质，在体内的多种关键生理和病理过程中发挥着重要作用，包括血管舒张、抗感染、抗肿瘤、抗炎和血管生成。在结直肠癌（CRC）中，观察到产生 HS 的酶异常过表达。由于 HS 对癌细胞的增殖、生长和死亡起着重要作用，因此 HS 可以作为癌症治疗的潜在靶点。在这篇综述中，我们从以下几个方面深入分析了 HS 在 CRC 中的作用机制：CRC 细胞中 HS 的合成和分解代谢及其对细胞信号转导途径的影响；不同浓度的外源性 HS 供体对 CRC 细胞生长的抑制作用及其在大蒜等天然产物中 HS 的作用机制。此外，我们阐明了 HS 在 CRC 中的表达特征，并构建了一个全面的 HS 相关信号通路网络，这对于促进 HS 相关药物的临床研究具有重要的基础和实际意义。
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