Deininger-Czermak E, Spencer L, Zoelch N, Sankar A, Gascho D, Guggenberger R, Mathieu S, Thali M J, Blumberg H P
Department of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland.
Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Mol Psychiatry. 2025 Mar;30(3):1029-1033. doi: 10.1038/s41380-024-02730-2. Epub 2024 Sep 5.
In vivo neuroimaging research in suicide attempters has shown alterations in frontal system brain regions subserving emotional regulation, motivation, and self-perception; however, data from living individuals is limited in clarifying risk for suicide death. Postmortem neuroimaging provides an approach to study the brain in persons who died by suicide. Here, whole brain voxel-based analyses of magnetic resonance imaging gray matter volume measures were performed comparing persons confirmed by forensic investigation to have died by suicide (n = 24), versus other causes (n = 24), in a univariate model covarying for age and total brain volume; all subjects were scanned within 24 hours after death. Consistent with the hypothesis that persons who died by suicide would show lower gray matter volume in frontal system brain regions, this study of suicides showed lower gray matter volume in ventral frontal and its major connection sites including insula, striatum, and amygdala.
对自杀未遂者进行的活体神经影像学研究表明，在负责情绪调节、动机和自我认知的额叶系统脑区存在改变；然而，来自在世个体的数据在阐明自杀死亡风险方面存在局限性。尸检神经影像学提供了一种研究自杀死亡者大脑的方法。在此，进行了基于磁共振成像灰质体积测量的全脑体素分析，在一个对年龄和全脑体积进行协变量调整的单变量模型中，比较经法医调查确认死于自杀的人（n = 24）与死于其他原因的人（n = 24）；所有受试者均在死后24小时内进行扫描。与自杀死亡者在额叶系统脑区灰质体积较低的假设一致，这项对自杀者的研究显示腹侧额叶及其主要连接部位（包括岛叶、纹状体和杏仁核）的灰质体积较低。
