Macias J M, Martin W J, Lloyd C W
Am J Hosp Pharm. 1985 May;42(5):1087-94.
The compatibility, stability, and availability of morphine sulfate and meperidine hydrochloride prepared in total parenteral nutrient (TPN) solution, 5% dextrose injection, and sterile water for injection in polyvinyl chloride (PVC) bags were evaluated. A 300-mg dose of each narcotic was mixed in 0.25-L bags of 5% dextrose injection and sterile water for injection, and in 3-L bags of TPN and sterile water for injection. Each solution was examined visually for precipitation, color change, turbidity, and the evolution of gas immediately after the addition of the drug to the bag and every 12 hours for a 36-hour period. Narcotic concentrations in each solution were determined by high-pressure liquid chromatography before and for 36 hours after the addition of the drugs to the bags. No loss of either drug because of adsorption to the PVC bags was found. Morphine sulfate and meperidine hydrochloride were chemically compatible and stable in TPN and 5% dextrose injection for 36 hours. Solutions of morphine sulfate or meperidine hydrochloride in PVC bags containing TPN or 5% dextrose injection are visually and chemically compatible, as well as stable and available for 36 hours when stored at 21.5 degrees C with no protection from environmental light.
评估了硫酸吗啡和盐酸哌替啶在聚氯乙烯（PVC）袋中的全胃肠外营养（TPN）溶液、5%葡萄糖注射液及注射用水中制备后的相容性、稳定性和可用性。将每种麻醉剂300毫克的剂量分别混入0.25升的5%葡萄糖注射液袋和注射用水袋中，以及3升的TPN袋和注射用水袋中。在将药物加入袋中后立即以及在36小时内每12小时对每种溶液进行外观检查，观察有无沉淀、颜色变化、浑浊及气体产生。在将药物加入袋中之前以及之后36小时，通过高压液相色谱法测定每种溶液中的麻醉剂浓度。未发现因药物吸附到PVC袋上而导致任何一种药物损失。硫酸吗啡和盐酸哌替啶在TPN和5%葡萄糖注射液中36小时内化学性质相容且稳定。含有TPN或5%葡萄糖注射液的PVC袋中硫酸吗啡或盐酸哌替啶溶液在外观和化学性质上是相容的，并且在21.5摄氏度下储存且无环境光防护时，36小时内稳定且可用。
