*Temple University School of Podiatric Medicine, Philadelphia, PA. Dr. Angstadt is now with St. Luke's Hospital, Allentown, PA. Dr. Chun is now with Kent Hospital, Warwick, RI.
†Department of Pathology and Laboratory Medicine, Temple University School of Podiatric Medicine, Philadelphia, PA. Dr. Arriola is now with Department of Pathology, Cooper University Health Care, Camden, NJ, and Cooper Medical School of Rowan University, Camden, NJ.
J Am Podiatr Med Assoc. 2024 Jul-Aug;114(4). doi: 10.7547/23-073.
Tenosynovial giant cell tumor (TGCT) is a rare type of neoplasm that may be locally aggressive but is most often benign and can be divided into two subtypes: localized and diffuse. It tends to develop in the joints, bursae, and tendon sheaths primarily in the digits of the hand and less commonly in the forefoot. This soft-tissue mass has many possible differential diagnoses, including lipoma, ganglion cyst, plantar fibroma, and various sarcomas; surgical excision is usually indicated to reach a definitive diagnosis and rule out malignancy. We report a rare case of a 30-year-old woman with atypical plantar hallucal pain and a palpable mass on the plantar lateral aspect of the left hallux. Surgical excision and histopathologic evaluation confirmed a TGCT of the left hallucal flexor tendon sheath. Although it bears clinical resemblance to several other soft-tissue masses, TGCT has numerous pathognomonic features evident with advanced imaging and histologic analysis that help the physician obtain an accurate diagnosis and proceed with appropriate treatment.
腱鞘巨细胞瘤（TGCT）是一种罕见的肿瘤，可能具有局部侵袭性，但通常为良性，可分为局限性和弥漫性两种亚型。它主要发生在手的关节、滑囊和腱鞘，较少发生在前足。这种软组织肿块有许多可能的鉴别诊断，包括脂肪瘤、腱鞘囊肿、足底纤维瘤和各种肉瘤；通常需要手术切除以明确诊断并排除恶性肿瘤。我们报告了一例罕见的病例，一名 30 岁女性，左足大脚趾跖侧外侧有非典型的足底痛和可触及的肿块。手术切除和组织病理学评估证实为左足屈肌腱腱鞘 TGCT。尽管它与其他几种软组织肿块具有临床相似性，但 TGCT 具有许多特征性的特征，通过先进的影像学和组织学分析可以明显看出，这有助于医生做出准确的诊断并进行适当的治疗。
