Groupe de Recherche Clinique #32, Transplantation Et Thérapies Innovantes de La Cornée, Sorbonne Université, Hôpital National des 15-20, Paris, France.
Service d'ophtalmologie 5, Hôpital National des 15-20, 28 Rue de Charenton, 75012, Paris, France.
Sci Rep. 2024 Sep 7;14(1):20888. doi: 10.1038/s41598-024-71604-y.
Refractive error is becoming a significant public health issue. Photorefractive Keratectomy (PRK) is a corneal surface surgical technique that removes the corneal epithelium before stromal photoablation by ultraviolet radiation from the Excimer laser. We designed a retrospective study to characterize corneal remodeling after myopic Photorefractive Keratectomy and assess the accuracy of laser-predicted ablation depth (AD). This study took place in 15-20 National Ophthalmology Hospital, Paris, France. 150 eyes with preoperative manifest spherical equivalent between - 10.00D and - 0.25D and cylinder < 3D, treated with the WaveLight® EX500 laser between 01/2019 and 01/2023, were followed for at least three months. The main outcome measurements were postoperative changes in epithelial (ET) and stromal (ST) thicknesses measured with spectral domain optical coherence tomography and mean simulated keratometry (SimK) assessed with corneal topography. The central ET significantly decreased at M1, increased over the preoperative value from M1 to M6, and stabilized after M6. The increase in central ET after M1 was associated with an increase in mean SimK (r = 0.34). The achieved AD was 7.9 ± 8.0 µm greater than the laser-predicted AD. Stromal over-ablation was significantly and independently associated with myopia > 6D preoperative mean SimK > 44D and transepithelial procedures.
屈光不正正在成为一个重大的公共卫生问题。准分子激光角膜切削术（PRK）是一种角膜表面手术技术，通过准分子激光的紫外光在基质光蚀前去除角膜上皮。我们设计了一项回顾性研究，以描述近视性准分子激光角膜切削术后的角膜重塑，并评估激光预测的消融深度（AD）的准确性。这项研究在法国巴黎的 15-20 国家眼科医院进行。在 2019 年 1 月至 2023 年 1 月期间，我们对 150 只术前等效球镜度数在-10.00D 至-0.25D 之间且柱镜度<3D 的眼睛使用 WaveLight® EX500 激光进行了治疗，随访时间至少为 3 个月。主要的观察指标是用光谱域光相干断层扫描测量的术后上皮（ET）和基质（ST）厚度的变化，以及用角膜地形图评估的平均模拟角膜曲率（SimK）。在 M1 时中央 ET 明显减少，从 M1 到 M6 时超过术前值，M6 后稳定。M1 后中央 ET 的增加与平均 SimK 的增加（r=0.34）相关。实际 AD 比激光预测 AD 高 7.9±8.0µm。基质过度消融与术前平均 SimK>6D、>44D 和经上皮程序显著且独立相关。
