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6岁以下儿童先天性胆管扩张症微创手术的特点及结果:儿童与成人的比较

Characteristics and outcomes of minimally invasive surgery for congenital biliary dilatation in children aged <6 years: Comparison between children and adults.

作者信息

Nakagawa Yoichi, Uchida Hiroo, Shirota Chiyoe, Tainaka Takahisa, Makita Satoshi, Satomi Miwa, Yasui Akihiro, Kano Yoko, Kato Daiki, Maeda Takuya

机构信息

Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.

出版信息

J Hepatobiliary Pancreat Sci. 2024 Dec;31(12):876-885. doi: 10.1002/jhbp.12069. Epub 2024 Sep 8.

DOI:10.1002/jhbp.12069
PMID:39245879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11660993/
Abstract

BACKGROUND/PURPOSE: We evaluated the minimally invasive surgery for congenital biliary dilatation (CBD) in adults and children and analyzed the surgical outcomes, especially in children aged <6 years.

METHODS

Characteristics and surgical outcomes of patients with CBD who underwent minimally invasive surgery at our hospital between 2013 and 2023 were retrospectively reviewed.

RESULTS

Overall, 129 patients (89 children aged <6 years, 9 children aged between 6 and 18 years, and 21 adults) were included in this study. Children exhibited more protein plug presence and abnormal biochemical data than adults. Incidence of postoperative pancreatic fistulas was highest in the adult group (3.4%, 11%, and 33%, respectively, p < .01). In children aged <6 years, postoperative bile leakage and pancreatic fistulas occurred in 9.0% and 3.4% of patients, respectively. Multivariate logistic regression analysis revealed that the Todani IVA was associated with a decrease in postoperative bile leakage (odds ratio: -1.7; 95% confidence interval: (-3.3)-(-0.22), p = .03).

CONCLUSION

Adults with CBD required prolonged operative times and had more short-term complications than children with CBD. In children aged <6 years, minimally invasive surgery for CBD can be safely performed; however, a small diameter of the bile duct may be associated with bile leakage.

摘要

背景/目的:我们评估了成人和儿童先天性胆管扩张症(CBD)的微创手术,并分析了手术结果,尤其是6岁以下儿童的手术结果。

方法

回顾性分析了2013年至2023年在我院接受微创手术的CBD患者的特征和手术结果。

结果

本研究共纳入129例患者(89例6岁以下儿童、9例6至18岁儿童和21例成人)。儿童比成人表现出更多的蛋白栓存在和异常生化数据。成人组术后胰瘘发生率最高(分别为3.4%、11%和33%,p<0.01)。在6岁以下儿童中,术后胆漏和胰瘘的发生率分别为9.0%和3.4%。多因素logistic回归分析显示,Todani IVA与术后胆漏的减少有关(比值比:-1.7;95%置信区间:(-3.3)-(-0.22),p=0.03)。

结论

CBD成人患者的手术时间较长,短期并发症比CBD儿童患者更多。对于6岁以下儿童,CBD的微创手术可以安全进行;然而,胆管直径较小可能与胆漏有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e798/11660993/37265a34e641/JHBP-31-876-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e798/11660993/37265a34e641/JHBP-31-876-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e798/11660993/37265a34e641/JHBP-31-876-g001.jpg

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本文引用的文献

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J Hepatobiliary Pancreat Sci. 2023 Nov;30(11):1241-1248. doi: 10.1002/jhbp.1381. Epub 2023 Oct 25.
2
Robotic versus laparoscopic radical surgery for pediatric congenital biliary dilatation: a comparison of surgical outcomes of a single surgeon's initial experience.机器人与腹腔镜根治术治疗小儿先天性胆管扩张症:单外科医生初始经验的手术结果比较。
Pediatr Surg Int. 2023 Sep 3;39(1):261. doi: 10.1007/s00383-023-05548-1.
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Usefulness of hepatobiliary scintigraphy for predicting late complications in patients with choledochal cysts.
肝胆闪烁显像术对预测胆总管囊肿患者晚期并发症的价值。
Pediatr Surg Int. 2022 Dec;38(12):1839-1845. doi: 10.1007/s00383-022-05241-9. Epub 2022 Sep 20.
4
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J Hepatobiliary Pancreat Sci. 2023 Apr;30(4):473-481. doi: 10.1002/jhbp.1235. Epub 2022 Sep 11.
5
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