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用于治疗炎症性肠病的结肠靶向给药系统的设计策略、进展及未来展望。

Design strategies, advances and future perspectives of colon-targeted delivery systems for the treatment of inflammatory bowel disease.

作者信息

Zheng Baoxin, Wang Liping, Yi Yan, Yin Jun, Liang Aihua

机构信息

Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.

School of Traditional Chinese Material, Shenyang Pharmaceutical University, Shenyang 110016, China.

出版信息

Asian J Pharm Sci. 2024 Aug;19(4):100943. doi: 10.1016/j.ajps.2024.100943. Epub 2024 Jul 14.

DOI:10.1016/j.ajps.2024.100943
PMID:39246510
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11375318/
Abstract

Inflammatory bowel diseases (IBD) significantly contribute to high mortality globally and negatively affect patients' qualifications of life. The gastrointestinal tract has unique anatomical characteristics and physiological environment limitations. Moreover, certain natural or synthetic anti-inflammatory drugs are associated with poor targeting, low drug accumulation at the lesion site, and other side effects, hindering them from exerting their therapeutic effects. Colon-targeted drug delivery systems represent attractive alternatives as novel carriers for IBD treatment. This review mainly discusses the treatment status of IBD, obstacles to drug delivery, design strategies of colon-targeted delivery systems, and perspectives on the existing complementary therapies. Moreover, based on recent reports, we summarized the therapeutic mechanism of colon-targeted drug delivery. Finally, we addressed the challenges and future directions to facilitate the exploitation of advanced nanomedicine for IBD therapy.

摘要

炎症性肠病（IBD）在全球范围内显著导致高死亡率，并对患者的生活质量产生负面影响。胃肠道具有独特的解剖学特征和生理环境限制。此外，某些天然或合成抗炎药物存在靶向性差、病变部位药物蓄积低以及其他副作用等问题，阻碍了它们发挥治疗作用。结肠靶向给药系统作为IBD治疗的新型载体，是有吸引力的替代方案。本综述主要讨论了IBD的治疗现状、药物递送的障碍、结肠靶向递送系统的设计策略以及现有辅助疗法的前景。此外，基于近期报道，我们总结了结肠靶向给药的治疗机制。最后，我们阐述了挑战和未来方向，以促进先进纳米药物在IBD治疗中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d952/11375318/d5e80491c5a3/gr12.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d952/11375318/a8afe2221357/gr1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d952/11375318/b9b09cf7f9ae/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d952/11375318/4b8610d1b13d/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d952/11375318/7ab0fa867aec/gr9.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d952/11375318/2e5ceca41b92/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d952/11375318/d5e80491c5a3/gr12.jpg

相似文献

[1]
Design strategies, advances and future perspectives of colon-targeted delivery systems for the treatment of inflammatory bowel disease.

Asian J Pharm Sci. 2024-8

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
Nanoparticle-Mediated Drug Delivery Systems For The Treatment Of IBD: Current Perspectives.

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[10]
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引用本文的文献

[1]
Advanced oral drug delivery systems for gastrointestinal targeted delivery: the design principles and foundations.

J Nanobiotechnology. 2025-5-30

[2]
Oral dosage forms for drug delivery to the colon: an existing gap between research and commercial applications.

J Mater Sci Mater Med. 2025-3-5

[3]
pH-Dependent Drug Delivery Systems for Ulcerative Colitis Treatment.

Pharmaceutics. 2025-2-10

本文引用的文献

[1]
Glucocorticoids-based prodrug design: Current strategies and research progress.

Asian J Pharm Sci. 2024-6

[2]
The landscape of small-molecule prodrugs.

Nat Rev Drug Discov. 2024-5

[3]
Strategies for targeting cytokines in inflammatory bowel disease.

Nat Rev Immunol. 2024-8

[4]
Nanotechnology's frontier in combatting infectious and inflammatory diseases: prevention and treatment.

Signal Transduct Target Ther. 2024-2-21

[5]
Mucoadhesive and thermosensitive Bletilla striata polysaccharide/chitosan hydrogel loaded nanoparticles for rectal drug delivery in ulcerative colitis.

Int J Biol Macromol. 2024-1

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Chem Soc Rev. 2024-2-5

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Gels. 2023-12-4

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3D-printed prednisolone phosphate suppositories with tunable dose and rapid release for the treatment of inflammatory bowel disease.

Int J Pharm. 2024-1-5

[9]
Orally Administrated Inflamed Colon-Targeted Nanotherapeutics for Inflammatory Bowel Disease Treatment by Oxidative Stress Level Modulation in Colitis.

ACS Nano. 2023-12-12

[10]
Triggerable Prodrug Nanocoating Enables On-Demand Activation of Microbial and Small-Molecular Therapeutics for Combination Treatment.

J Am Chem Soc. 2023-12-13

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