Fotakopoulos George, Christodoulidis Grigorios, Georgakopoulou Vasiliki Epameinondas, Trakas Nikolaos, Skapani Pagona, Panagiotopoulos Konstantinos, Spandidos Demetrios A, Foroglou Nicolas
Department of Neurosurgery, General University Hospital of Larisa, 41221 Larisa, Greece.
Department of General Surgery, General University Hospital of Larisa, 41221 Larisa, Greece.
Mol Clin Oncol. 2024 Aug 19;21(5):77. doi: 10.3892/mco.2024.2775. eCollection 2024 Nov.
Gastric cancer (GC) constitutes one of the most wide-ranging cancers, with brain metastasis (BM) being a markedly uncommon and unfavorable outcome. The present meta-analysis evaluated the relationship between no-surgical treatment vs. additional surgical BM resection on the patient's quality of life and potential survival using electronic databases, including PubMed (1980-April 2024), Medline (1980-April 2024), Cochrane Library, and EMBASE (1980-April 2024). After a literature search, six articles were included in the final study pool. The number of patients with BM and conservative treatment was 289 (80.05%) compared with those that underwent an additional surgical resection 72 (19.95%). The mean age was 59.2 years, and the males were 195 (73.8%) of 264 available from five studies. The findings of the present meta-analysis revealed that the curative effect of BM tumor resection on patients with GC undergoing additional treatment with stereotactic radiosurgery, whole-brain radiotherapy or chemotherapy was favorable for their survival.
胃癌（GC）是最广泛的癌症之一，脑转移（BM）是一种明显罕见且预后不良的情况。本荟萃分析使用电子数据库，包括PubMed（1980年 - 2024年4月）、Medline（1980年 - 2024年4月）、Cochrane图书馆和EMBASE（1980年 - 2024年4月），评估了非手术治疗与额外手术切除脑转移瘤对患者生活质量和潜在生存期的关系。经过文献检索，最终研究库纳入了6篇文章。接受脑转移瘤保守治疗的患者有289例（80.05%），而接受额外手术切除的患者有72例（19.95%）。平均年龄为59.2岁，在五项研究中可获得的264例患者中，男性有195例（73.8%）。本荟萃分析的结果显示，对于接受立体定向放射外科、全脑放疗或化疗等额外治疗的胃癌脑转移患者，脑转移瘤切除的疗效对其生存有利。
