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胶质母细胞瘤：治疗概述及磁共振波谱分析

Glioblastoma: Overview and Magnetic Resonance Spectroscopy Analysis for Treatment.

作者信息

Syed Waseem, Ibatullin Murat

机构信息

Medical Imaging, Lake Erie College of Osteopathic Medicine, Bradenton, USA.

出版信息

Cureus. 2024 Aug 7;16(8):e66390. doi: 10.7759/cureus.66390. eCollection 2024 Aug.

DOI:10.7759/cureus.66390
PMID:39247004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11379102/
Abstract

Glioblastoma multiforme (GBM) is a very aggressive and fast-growing cancer of the brain that has a low life expectancy. Many new cases are diagnosed every year with each having a very poor prognosis. It is therefore of utmost concern to develop cures for such a devastating condition. Magnetic resonance spectroscopy details certain peaks that are of interest. In particular, later-stage astrocytomas exhibit prominent choline and creatine peaks. The creatine peak is known to enhance glioblastoma survival.

摘要

多形性胶质母细胞瘤（GBM）是一种极具侵袭性且生长迅速的脑癌，患者预期寿命较短。每年都有许多新病例被诊断出来，每个病例的预后都非常差。因此，研发针对这种毁灭性疾病的治疗方法至关重要。磁共振波谱详细显示了某些感兴趣的峰。特别是，晚期星形细胞瘤表现出明显的胆碱和肌酸峰。已知肌酸峰可提高胶质母细胞瘤的生存率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/e7c745c4a3ec/cureus-0016-00000066390-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/79ea76a48352/cureus-0016-00000066390-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/8075e4264396/cureus-0016-00000066390-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/597e6825f50e/cureus-0016-00000066390-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/40ae99c12a94/cureus-0016-00000066390-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/491e725c0520/cureus-0016-00000066390-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/b3243bac1167/cureus-0016-00000066390-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/528854ec250f/cureus-0016-00000066390-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/113e330f961f/cureus-0016-00000066390-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/36f97a3b7fc5/cureus-0016-00000066390-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/e7c745c4a3ec/cureus-0016-00000066390-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/79ea76a48352/cureus-0016-00000066390-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/8075e4264396/cureus-0016-00000066390-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/597e6825f50e/cureus-0016-00000066390-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/40ae99c12a94/cureus-0016-00000066390-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/491e725c0520/cureus-0016-00000066390-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/b3243bac1167/cureus-0016-00000066390-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/528854ec250f/cureus-0016-00000066390-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/113e330f961f/cureus-0016-00000066390-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/36f97a3b7fc5/cureus-0016-00000066390-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbe6/11379102/e7c745c4a3ec/cureus-0016-00000066390-i10.jpg

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本文引用的文献

1
Magnetic Resonance Spectroscopy in Diagnosis and Follow-Up of Gliomas: State-of-the-Art.磁共振波谱在神经胶质瘤诊断与随访中的应用：最新进展
Cancers (Basel). 2022 Jun 29;14(13):3197. doi: 10.3390/cancers14133197.
2
The 2021 WHO Classification of Tumors of the Central Nervous System: a summary.2021 年世卫组织中枢神经系统肿瘤分类：概述。
Neuro Oncol. 2021 Aug 2;23(8):1231-1251. doi: 10.1093/neuonc/noab106.
3
VEGF Manipulation in Glioblastoma.胶质母细胞瘤中的血管内皮生长因子调控
Oncology (Williston Park). 2015 Oct;29(10):720-7.
4
Visualization of microvascularity in glioblastoma multiforme with 8-T high-spatial-resolution MR imaging.使用8-T高空间分辨率磁共振成像对多形性胶质母细胞瘤微血管进行可视化。
AJNR Am J Neuroradiol. 2002 Oct;23(9):1553-6.