Zhang Jinghan, Jin Kangyu, Chen Bing, Cheng Shangping, Jin Jinfan, Yang Xiaolan, Lu Jing, Song Qinghai
Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou, 310003, China.
Heliyon. 2024 Aug 15;10(16):e36402. doi: 10.1016/j.heliyon.2024.e36402. eCollection 2024 Aug 30.
The orexin system regulates a variety of physiological functions, including the sleep-wake cycle, addiction, foraging behavior, stress and cognitive functioning. Orexin levels in central and peripheral are related to the pathogenesis of many diseases, most notably the narcolepsy, eating disorders, stress-related psychiatric disorders, and neurodegenerative diseases. Recently, it has been reported that the orexin system is distinctly sexually dimorphic, and is strongly associated with neuropsychiatric disorders. In this review, we analyzed advancements in the sex differences in the orexin system and their connection to psychoneurological conditions. Considering the scarcity of research in this domain, more research is imperative to reveal the underlying mechanisms.
食欲素系统调节多种生理功能，包括睡眠-觉醒周期、成瘾、觅食行为、应激和认知功能。中枢和外周的食欲素水平与许多疾病的发病机制有关，最显著的是发作性睡病、饮食失调、应激相关精神障碍和神经退行性疾病。最近，有报道称食欲素系统存在明显的性别差异，并与神经精神障碍密切相关。在这篇综述中，我们分析了食欲素系统性别差异的研究进展及其与精神神经疾病的联系。鉴于该领域研究的匮乏，必须开展更多研究以揭示其潜在机制。
