Aerobic Exercise Training for the Aging Brain: Effective Dosing and Vascular Mechanism.

This article presents evidence supporting the hypothesis that starting aerobic exercise in early adulthood and continuing it throughout life leads to significant neurocognitive benefits compared with starting exercise later in life. Regular aerobic exercise at moderate-to-vigorous intensity during midlife is associated with significant improvement in cardiorespiratory fitness, which may create a favorable brain microenvironment promoting neuroplasticity through enhanced vascular function.