Wu Rongrong, Zong Hui, Feng Weizhe, Zhang Ke, Li Jiakun, Wu Erman, Tang Tong, Zhan Chaoying, Liu Xingyun, Zhou Yi, Zhang Chi, Zhang Yingbo, He Mengqiao, Ren Shumin, Shen Bairong
Department of Urology and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Department of Computer Science and Information Technologies, Elviña Campus, University of A Coruña, A Coruña, Spain.
Comput Struct Biotechnol J. 2024 Aug 17;24:561-570. doi: 10.1016/j.csbj.2024.08.015. eCollection 2024 Dec.
Patients with oligometastatic cancer (OMC) exhibit better response to local therapeutic interventions and a more treatable tendency than those with polymetastatic cancers. However, studies on OMC are limited and lack effective integration for systematic comparison and personalized application, and the diagnosis and precise treatment of OMC remain controversial. The application of large language models in medicine remains challenging because of the requirement of high-quality medical data. Moreover, these models must be enhanced using precise domain-specific knowledge. Therefore, we developed the OligoM-Cancer platform (http://oligo.sysbio.org.cn), pioneering knowledge curation that depicts various aspects of oligometastases spectrum, including markers, diagnosis, prognosis, and therapy choices. A user-friendly website was developed using HTML, FLASK, MySQL, Bootstrap, Echarts, and JavaScript. This platform encompasses comprehensive knowledge and evidence of phenotypes and their associated factors. With 4059 items of literature retrieved, OligoM-Cancer includes 1345 valid publications and 393 OMC-associated factors. Additionally, the included clinical assistance tools enhance the interpretability and credibility of clinical translational practice. OligoM-Cancer facilitates knowledge-guided modeling for deep phenotyping of OMC and potentially assists large language models in supporting specialised oligometastasis applications, thereby enhancing their generalization and reliability.
寡转移癌(OMC)患者比多转移癌患者对局部治疗干预表现出更好的反应和更易治疗的趋势。然而,关于OMC的研究有限,缺乏有效的整合以进行系统比较和个性化应用,OMC的诊断和精确治疗仍存在争议。由于对高质量医学数据的要求,大语言模型在医学中的应用仍然具有挑战性。此外,这些模型必须使用精确的特定领域知识进行增强。因此,我们开发了OligoM-Cancer平台(http://oligo.sysbio.org.cn),开创了知识整理工作,描绘了寡转移谱的各个方面,包括标志物、诊断、预后和治疗选择。使用HTML、FLASK、MySQL、Bootstrap、Echarts和JavaScript开发了一个用户友好的网站。该平台包含了表型及其相关因素的全面知识和证据。通过检索4059篇文献,OligoM-Cancer包括1345篇有效出版物和393个与OMC相关的因素。此外,所包含的临床辅助工具提高了临床转化实践的可解释性和可信度。OligoM-Cancer有助于进行知识引导的建模,以对OMC进行深度表型分析,并可能协助大语言模型支持专门的寡转移应用,从而提高其泛化能力和可靠性。