College of Chinese Medicinal Materials, Jilin Provincial International Joint Research Center for the Development and Utilization of Authentic Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China.
College of Chinese Medicinal Materials, Jilin Provincial International Joint Research Center for the Development and Utilization of Authentic Medicinal Materials, Jilin Agricultural University, Changchun, 130118, China; College of Life Sciences, Jilin Agricultural University, Changchun, 130118, China.
J Ethnopharmacol. 2025 Jan 30;337(Pt 1):118781. doi: 10.1016/j.jep.2024.118781. Epub 2024 Sep 12.
According to the Shen Nong Herbal Classic, Ginseng (Panax ginseng C.A. Meyer) is documented to possess life-prolonging effects and is extensively utilized in traditional Chinese medicine for the treatment of various ailments such as qi deficiency, temper deficiency, insomnia, and forgetfulness. Ginseng is commonly employed for replenishing qi and nourishing blood, fortifying the body and augmenting immunity; it has demonstrated efficacy in alleviating fatigue, enhancing memory, and retarding aging. Furthermore, it exhibits a notable ameliorative impact on age-related conditions including cardiovascular diseases and neurodegenerative disorders. One of its active constituents - ginsenoside Rg2 (G-Rg2) - exhibits potential therapeutic efficacy in addressing these ailments.
The aim of this review is to explore the traditional efficacy of ginseng in anti-aging diseases and the modern pharmacological mechanism of its potential active substance G-Rg2, in order to provide strong theoretical support for further elucidating the mechanism of its anti-aging effect.
This review provides a comprehensive analysis of the traditional efficacy of ginseng and the potential mechanisms underlying the anti-age-related disease properties of G-Rg2, based on an extensive literature review up to March 12, 2024, from PubMed, Web of Science, Scopus, Cochrane, and Google Scholar databases. Potential anti-aging mechanisms of G-Rg2 were predicted using network pharmacology and molecular docking analysis techniques.
In traditional Chinese medicine theory, ginseng has been shown to improve aging-related diseases with a variety of effects, including tonifying qi, strengthening the spleen and stomach, nourishing yin, regulating yin and yang, as well as calming the mind. Its potential active ingredient G-Rg2 has demonstrated significant therapeutic potential in age-related diseases, especially central nervous system and cardiovascular diseases. G-Rg2 exhibited a variety of pharmacological activities, including anti-apoptotic, anti-inflammatory and antioxidant effects. Meanwhile, the network pharmacological analyses and molecular docking results were consistent with the existing literature review, further validating the potential efficacy of G-Rg2 as an anti-aging agent.
The review firstly explores the ameliorative effects of ginseng on a wide range of age-related diseases based on TCM theories. Secondly, the article focuses on the remarkable significance and value demonstrated by G-Rg2 in age-related cardiovascular and neurodegenerative diseases. Consequently, G-Rg2 has broad prospects for development in intervening in aging and treating age-related health problems.
根据《神农本草经》记载，人参（Panax ginseng C.A. Meyer）具有延年益寿的功效，在传统中医中广泛用于治疗各种疾病，如气虚、脾气虚、失眠和健忘。人参常用于补气养血、强身健体、增强免疫力；它已被证明能有效缓解疲劳、增强记忆力和延缓衰老。此外，它对心血管疾病和神经退行性疾病等与年龄相关的疾病具有显著的改善作用。其一种活性成分——人参皂苷 Rg2（G-Rg2）——在治疗这些疾病方面具有潜在的治疗效果。
本综述的目的是探讨人参在抗衰老疾病方面的传统功效以及其潜在活性物质 G-Rg2 的现代药理学机制，为进一步阐明其抗衰老作用的机制提供强有力的理论支持。
本综述基于截至 2024 年 3 月 12 日从 PubMed、Web of Science、Scopus、Cochrane 和 Google Scholar 数据库进行的广泛文献回顾，全面分析了人参的传统功效和 G-Rg2 抗与年龄相关疾病的潜在机制。使用网络药理学和分子对接分析技术预测了 G-Rg2 的潜在抗衰老机制。
在中医理论中，人参已被证明可通过多种作用改善与衰老相关的疾病，包括补气、健脾和胃、滋阴、调节阴阳、以及安神。其潜在的活性成分 G-Rg2 在与年龄相关的疾病，特别是中枢神经系统和心血管疾病方面具有显著的治疗潜力。G-Rg2 表现出多种药理活性，包括抗凋亡、抗炎和抗氧化作用。同时，网络药理学分析和分子对接结果与现有文献综述一致，进一步验证了 G-Rg2 作为抗衰老剂的潜在功效。
本综述首先根据中医理论探讨了人参对多种与年龄相关疾病的改善作用。其次，文章重点介绍了 G-Rg2 在与年龄相关的心血管和神经退行性疾病方面的显著意义和价值。因此，G-Rg2 在干预衰老和治疗与年龄相关的健康问题方面具有广阔的发展前景。
