Dianatkhah Mehrnoush, Davoodi Zeinab Sadat, Soltani Rasool, Shafiee Fatemeh, Hosseini Alireza
Department of Clinical Pharmacy and Pharmacy Practice, Isfahan University of Medical Sciences, Isfahan, Iran.
Chamran Cardiovascular Medical and Research Hospital, Isfahan, Iran.
J Res Pharm Pract. 2024 Aug 8;12(4):135-140. doi: 10.4103/jrpp.jrpp_25_24. eCollection 2023 Oct-Dec.
According to the importance of evaluating the antimicrobial resistance pattern in the management of nosocomial infections (NIs), we decided to investigate the prevalence of antimicrobial resistance in Chamran Heart Hospital.
This retrospective cross-sectional observational study was performed for 6 months from February to July 2022 at Shahid Chamran Hospital of Isfahan, Iran. All hospitalized patients with any NIs were eligible for the study. Clinical specimens were obtained from patients with NIs. All specimens underwent microbial culture, and if bacterial growth developed, differential tests were performed. Antibiotic susceptibility testing also was performed per the standards of Clinical and Laboratory Standards Institute, 2022.
Out of 201 examined samples, urinary infection (34.83%), pneumonia (27.86%), and sepsis (13.43%) were reported to be the most prevalent infections. Among Gram-negatives (76.12%), spp. (26.37%), (24.87%), and spp. (11.44%) were the most common pathogens. About 54.9% of spp., 33.3% of . , and 45.45% of spp. were resistant to carbapenems. About 1.88% and 15% of spp. were identified as pan-drug-resistant bacteria and extensively drug-resistant (XDR), respectively. In addition, 4.34% of spp. were identified as XDR. Among Gram-positives (23.88%), spp. (8.95%) was identified as the most common pathogen, and the prevalence of methicillin-resistant (MRSA) and vancomycin-resistant (VRE) was 11.11% and 61.11%, respectively.
In our study, carbapenem-resistant Enterobacteriaceae accounts for about 50% of all NIs. Moreover, despite the low prevalence of MRSA, VRE was reported to be high in our center when compared with other studies.
鉴于评估抗菌药物耐药模式在医院感染（NI）管理中的重要性，我们决定调查恰姆兰心脏医院的抗菌药物耐药情况。
本回顾性横断面观察性研究于2022年2月至7月在伊朗伊斯法罕的沙希德·恰姆兰医院进行了6个月。所有患有任何医院感染的住院患者均符合研究条件。从医院感染患者中获取临床标本。所有标本均进行微生物培养，若有细菌生长，则进行鉴别试验。抗生素敏感性试验也按照2022年临床和实验室标准协会的标准进行。
在201份检测样本中，尿路感染（34.83%）、肺炎（27.86%）和败血症（13.43%）被报告为最常见的感染。在革兰氏阴性菌（76.12%）中， 菌属（26.37%）、 菌（24.87%）和 菌属（11.44%）是最常见的病原体。约54.9%的 菌属、33.3%的 菌、45.45%的 菌属对碳青霉烯类耐药。约1.88%的 菌属和15%的 菌属分别被鉴定为泛耐药菌和广泛耐药（XDR）菌。此外，4.34%的 菌属被鉴定为XDR菌。在革兰氏阳性菌（23.88%）中， 菌属（8.95%）被确定为最常见的病原体，耐甲氧西林 （MRSA）和耐万古霉素 （VRE）的患病率分别为11.11%和61.11%。
在我们的研究中，耐碳青霉烯类肠杆菌科细菌约占所有医院感染的5
