Gupta Abhishek, Chandra Smita, Munish Kanika
Pathology, Gautam Buddha Chikitsa Mahavidyalaya, Dehradun, IND.
Pathology, Himalayan Institute of Medical Sciences, Dehradun, IND.
Cureus. 2024 Aug 11;16(8):e66657. doi: 10.7759/cureus.66657. eCollection 2024 Aug.
Breast carcinoma is the second most frequent type of cancer globally, with an estimated 2.08 million new carcinoma cases identified in 2018. Breast cancer prognosis is influenced by a number of variables, including the patient's age, morphological variant, stromal inflammatory reaction, elastotic, fibrotic focus, lymphovascular emboli, recurrence of tumor, etc. Recently, the morphological evaluation and extent of tumor-infiltrating lymphocytes (TIL) have also been studied in breast cancer. An attempt is being made to understand the role of TIL in determining the prognostication of carcinoma breast. Thus, the goal of the current academic study is to assess TIL in breast carcinoma.
The study was performed at a medical institution's pathology department, which covered newly diagnosed cases of infiltrating ductal carcinoma of the breast on histopathology during the January to December 2019 time frame. The gross and hematoxyline-eosin-stained paraffin sections were studied for histopathological examination.
The study included 50 cases of infiltrating ductal carcinoma of the breast with a female-to-male ratio of 24:1. Stromal TIL was negative (0-10%) in 12 cases, while was positive (11-100 %) in 38 cases. The results of the receiver operating characteristic (ROC) curve study indicated that the specificity was 70.7% and the sensitivity was 85.3% when the cutoff of stromal TIL <11% was used to predict the live status of patients.
Stromal TIL is an important parameter that must be reported in breast carcinoma cases. Positive stromal TIL shows a statistically significant difference with pathological tumor-node-metastasis (pTNM) staging, tumor laterality, size of the tumor, and involvement of nipple and areola.
乳腺癌是全球第二常见的癌症类型，2018年估计有208万例新确诊的癌症病例。乳腺癌的预后受多种因素影响，包括患者年龄、形态学变异、间质炎症反应、弹性组织变性、纤维化灶、淋巴管栓子、肿瘤复发等。最近，肿瘤浸润淋巴细胞（TIL）的形态学评估及其在乳腺癌中的范围也受到了研究。人们试图了解TIL在确定乳腺癌预后中的作用。因此，当前学术研究的目标是评估乳腺癌中的TIL。
该研究在一家医疗机构的病理科进行，涵盖了2019年1月至12月期间组织病理学新诊断的浸润性导管癌病例。对大体标本和苏木精-伊红染色的石蜡切片进行组织病理学检查。
该研究纳入50例乳腺浸润性导管癌病例，男女比例为24:1。间质TIL在12例中为阴性（0-10%），而在38例中为阳性（11-100%）。受试者工作特征（ROC）曲线研究结果表明，当使用间质TIL<11%的临界值来预测患者的生存状态时，特异性为70.7%，敏感性为85.3%。
间质TIL是乳腺癌病例中必须报告的一个重要参数。阳性间质TIL与病理肿瘤-淋巴结-转移（pTNM）分期、肿瘤侧别、肿瘤大小以及乳头和乳晕受累情况存在统计学显著差异。
