Postgraduate Program in Pathology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Postgraduate Program in Medical Sciences, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Biomark Med. 2024 Aug 17;18(15-16):649-658. doi: 10.1080/17520363.2024.2377532. Epub 2024 Sep 12.
To evaluate the urinary biomarkers related to sepsis in preterm newborns (NBs) and to investigate the predictive capacity of these biomarkers for a longer hospital stay. Serum and urine were collected from 27 healthy NBs, 24 NBs with neonatal infection without sepsis and 11 NBs with sepsis for the measurement of sindecan-1, lipocalin associated with urinary neutrophil gelatinase (uNGAL), urinary cystatin-C (uCysC) and urinary kidney injury molecule-1. Levels of uNGAL and urinary cystatin-C were elevated in NBs with sepsis and neonatal infection, and uNGAL was significant predictor of hospital stay longer than 30 days (odds ratio: 1.052; 95% CI: 1.012-1.093; = 0.01). uNGAL was associated with sepsis in preterm NBs and was useful to predict extended hospital stay.
评估与早产儿败血症相关的尿生物标志物，并研究这些生物标志物对延长住院时间的预测能力。
采集 27 例健康早产儿、24 例无败血症新生儿感染和 11 例败血症早产儿的血清和尿液，用于检测 syndecan-1、尿中性粒细胞明胶酶相关脂质运载蛋白(uNGAL)、尿胱抑素-C(uCysC)和尿肾损伤分子-1。
败血症和新生儿感染的早产儿 uNGAL 和尿胱抑素-C 水平升高，uNGAL 是住院时间超过 30 天的显著预测因子（比值比：1.052；95%可信区间：1.012-1.093；P=0.01）。
uNGAL 与早产儿败血症相关，有助于预测延长住院时间。
