尿胱抑素-C 和尿中性粒细胞明胶酶相关脂质运载蛋白与败血症相关，可预测早产儿的住院时间延长。
Urinary cystatin-C and urinary NGAL associated with sepsis predicts longer hospital stay in premature newborns.
机构信息
Postgraduate Program in Pathology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Postgraduate Program in Medical Sciences, Federal University of Ceará, Fortaleza, Ceará, Brazil.
出版信息
Biomark Med. 2024 Aug 17;18(15-16):649-658. doi: 10.1080/17520363.2024.2377532. Epub 2024 Sep 12.
To evaluate the urinary biomarkers related to sepsis in preterm newborns (NBs) and to investigate the predictive capacity of these biomarkers for a longer hospital stay. Serum and urine were collected from 27 healthy NBs, 24 NBs with neonatal infection without sepsis and 11 NBs with sepsis for the measurement of sindecan-1, lipocalin associated with urinary neutrophil gelatinase (uNGAL), urinary cystatin-C (uCysC) and urinary kidney injury molecule-1. Levels of uNGAL and urinary cystatin-C were elevated in NBs with sepsis and neonatal infection, and uNGAL was significant predictor of hospital stay longer than 30 days (odds ratio: 1.052; 95% CI: 1.012-1.093; = 0.01). uNGAL was associated with sepsis in preterm NBs and was useful to predict extended hospital stay.
目的
评估与早产儿败血症相关的尿生物标志物，并研究这些生物标志物对延长住院时间的预测能力。
方法
采集 27 例健康早产儿、24 例无败血症新生儿感染和 11 例败血症早产儿的血清和尿液，用于检测 syndecan-1、尿中性粒细胞明胶酶相关脂质运载蛋白(uNGAL)、尿胱抑素-C(uCysC)和尿肾损伤分子-1。
结果
败血症和新生儿感染的早产儿 uNGAL 和尿胱抑素-C 水平升高，uNGAL 是住院时间超过 30 天的显著预测因子（比值比：1.052；95%可信区间：1.012-1.093；P=0.01）。
结论
uNGAL 与早产儿败血症相关，有助于预测延长住院时间。
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