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尿胱抑素-C 和尿中性粒细胞明胶酶相关脂质运载蛋白与败血症相关，可预测早产儿的住院时间延长。

Urinary cystatin-C and urinary NGAL associated with sepsis predicts longer hospital stay in premature newborns.

机构信息

Postgraduate Program in Pathology, Federal University of Ceará, Fortaleza, Ceará, Brazil.

Postgraduate Program in Medical Sciences, Federal University of Ceará, Fortaleza, Ceará, Brazil.

出版信息

Biomark Med. 2024 Aug 17;18(15-16):649-658. doi: 10.1080/17520363.2024.2377532. Epub 2024 Sep 12.

DOI:10.1080/17520363.2024.2377532
PMID:39263780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11404570/
Abstract

To evaluate the urinary biomarkers related to sepsis in preterm newborns (NBs) and to investigate the predictive capacity of these biomarkers for a longer hospital stay. Serum and urine were collected from 27 healthy NBs, 24 NBs with neonatal infection without sepsis and 11 NBs with sepsis for the measurement of sindecan-1, lipocalin associated with urinary neutrophil gelatinase (uNGAL), urinary cystatin-C (uCysC) and urinary kidney injury molecule-1. Levels of uNGAL and urinary cystatin-C were elevated in NBs with sepsis and neonatal infection, and uNGAL was significant predictor of hospital stay longer than 30 days (odds ratio: 1.052; 95% CI: 1.012-1.093;  = 0.01). uNGAL was associated with sepsis in preterm NBs and was useful to predict extended hospital stay.

摘要

目的：评估与早产儿败血症相关的尿生物标志物，并研究这些生物标志物对延长住院时间的预测能力。

方法：采集 27 例健康早产儿、24 例无败血症新生儿感染和 11 例败血症早产儿的血清和尿液，用于检测 syndecan-1、尿中性粒细胞明胶酶相关脂质运载蛋白(uNGAL)、尿胱抑素-C(uCysC)和尿肾损伤分子-1。

结果：败血症和新生儿感染的早产儿 uNGAL 和尿胱抑素-C 水平升高，uNGAL 是住院时间超过 30 天的显著预测因子（比值比：1.052；95%可信区间：1.012-1.093；P=0.01）。

结论：uNGAL 与早产儿败血症相关，有助于预测延长住院时间。

相似文献

[1]
Urinary cystatin-C and urinary NGAL associated with sepsis predicts longer hospital stay in premature newborns.

Biomark Med. 2024-8-17

[2]
Serum and urinary biomarkers to predict acute kidney injury in premature infants: a systematic review and meta-analysis of diagnostic accuracy.

J Nephrol. 2022-11

[3]
Impact of severe sepsis on serum and urinary biomarkers of acute kidney injury in critically ill children: an observational study.

Blood Purif. 2013-2-15

[4]
Time Course of Kidney Injury Biomarkers in Children With Septic Shock: Nested Cohort Study Within the Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis Trial.

Pediatr Crit Care Med. 2025-6-1

[5]
Neutrophil gelatinase-associated lipocalin as predictor of acute kidney injury in neonates with perinatal asphyxia: a systematic review and meta-analysis.

Eur J Pediatr. 2018-7-26

[6]
Is plasma neutrophil gelatinase-associated lipocalin a predictive biomarker for acute kidney injury in sepsis patients? A systematic review and meta-analysis.

J Crit Care. 2016-6

[7]
Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis.

Am J Kidney Dis. 2009-12

[8]
Diagnostic value of neutrophil gelatinase-associated lipocalin, cystatin C, and soluble triggering receptor expressed on myeloid cells-1 in critically ill patients with sepsis-associated acute kidney injury.

Crit Care. 2015-5-6

[9]
Neutrophil gelatinase-associated lipocalin is elevated in children with acute kidney injury and sickle cell anemia, and predicts mortality.

Kidney Int. 2022-10

[10]
The use of plasma and urine neutrophil gelatinase associated lipocalin (NGAL) and Cystatin C in early diagnosis of septic acute kidney injury in critically ill patients.

Dis Markers. 2013

引用本文的文献

[1]
Genotype-Phenotype Correlation of TNF-α (-238, rs361525) and Cystatin C for Early Detection of Sepsis-Associated AKI and Its Severity in Critically Ill Neonates.

Int J Mol Sci. 2025-7-14

本文引用的文献

[1]
Prognostic value of serum cystatin C in patients with sepsis.

Indian J Pathol Microbiol. 2023

[2]
The Review of Current Knowledge on Neutrophil Gelatinase-Associated Lipocalin (NGAL).

Int J Mol Sci. 2023-6-21

[3]
Role of Neutrophil Gelatinase-associated Lipocalin (NGAL) and Other Clinical Parameters as Predictors of Bacterial Sepsis in Patients Presenting to the Emergency Department with Fever.

Indian J Crit Care Med. 2023-3

[4]
Use of non-conventional biomarkers in the early diagnosis of acute kidney injury in preterm newborns with sepsis.

J Bras Nefrol. 2022

[5]
Neonatal Sepsis: A Review of Pathophysiology and Current Management Strategies.

Adv Neonatal Care. 2021-2-1

[6]
Urinary NMR Profiling in Pediatric Acute Kidney Injury-A Pilot Study.

Int J Mol Sci. 2020-2-11

[7]
A long journey for acute kidney injury biomarkers.

Ren Fail. 2020-11

[8]
Using Score for Neonatal Acute Physiology Perinatal Extension II (SNAPPE II) in Neonates with Acute Kidney Injury.

Open Access Maced J Med Sci. 2019-9-14

[9]
[Acute kidney injury in the newborn: a consensus statement].

Arch Argent Pediatr. 2020-2

[10]
Acute Renal Failure in the Neonate.

J Pediatr Intensive Care. 2016-6

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