Chen Baohong, He Bingzhi, Tucker Alexander M, Biluck Ian, Leung Thomas H, Schaer Thomas P, Yang Shu
Department of Materials Science and Engineering, University of Pennsylvania, 3231 Walnut Street, Philadelphia, PA, 19104, USA.
Department of Surgery, Division of Neurosurgery, Center for Data Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA, 19104, USA.
Adv Healthc Mater. 2024 Dec;13(31):e2400827. doi: 10.1002/adhm.202400827. Epub 2024 Sep 12.
Reversible adhesives for wound care improve patient experiences by permitting reuse and minimizing further tissue injury. Existing reversible bandages are vulnerable to water and can undergo unwanted deformation during removal and readdressing procedures. Here, a biocompatible, multilayered, reversible wound dressing film that conforms to skin and is waterproof is designed. The inner layer is capable of instant adhesion to various substrates upon activation of the dynamic boronic ester bonds by water; intermediate hydrogel layer and outer silicone backing layer can enhance the dressing's elasticity and load distribution for adhesion, and the silicone outer layer protects the dressing from exposure to water. The adhesive layer is found to be biocompatible with mouse skin. Skin injuries on the mouse skin heal more rapidly with the film compared to no dressing controls. Evaluations of the film on skin of freshly euthanized minipigs corroborate the findings in the mouse model. The film remains attached to skins without delamination despite subjecting to various degrees of deformation. Exposure to water softens the film to allow removal from the skin without pulling any hair off. The multilayered design considers soft mechanics in each layer and will offer new insights to improve wound dressing performance and patient comfort.
用于伤口护理的可逆粘合剂通过允许重复使用和最大限度减少进一步的组织损伤来改善患者体验。现有的可逆绷带易受水的影响，并且在去除和重新包扎过程中可能会发生不必要的变形。在此，设计了一种与皮肤贴合且防水的生物相容性多层可逆伤口敷料薄膜。内层在水激活动态硼酸酯键后能够立即与各种基材粘附；中间水凝胶层和外部硅树脂背衬层可增强敷料的弹性和粘附的负荷分布，并且硅树脂外层可保护敷料免受水的影响。发现粘合剂层与小鼠皮肤具有生物相容性。与未进行敷料处理的对照组相比，用该薄膜处理的小鼠皮肤损伤愈合得更快。在刚安乐死的小型猪皮肤上对该薄膜进行的评估证实了小鼠模型中的研究结果。尽管经受了不同程度的变形，该薄膜仍能附着在皮肤上而不会分层。接触水会使薄膜变软，从而可以从皮肤上移除而不会拔掉任何毛发。这种多层设计考虑了每层中的软力学，将为改善伤口敷料性能和患者舒适度提供新的见解。
