Louzada Lidiane M, Hildebrand Hauke, Neuhaus Klaus W, Duncan Henry F
Division of Endodontics, Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, Brazil.
Division of Restorative Dentistry and Periodontology, Trinity College Dublin, Dublin Dental University Hospital, Dublin, Ireland.
Int Endod J. 2025 Jan;58(1):37-54. doi: 10.1111/iej.14149. Epub 2024 Sep 12.
Pulpitis may be pain free or alternatively characterized by mild to severe pain and associated symptoms. Evidence has recently emerged that patients presenting with carious pulp exposure range of symptoms can be treated effectively with pulpotomy.
The current systematic review aimed to answer the following research question: "In patients with deep caries lesions in permanent teeth associated with no symptoms, reversible pulpitis or signs and symptoms indicative of irreversible pulpitis (P), is partial pulpotomy (I) as effective as full pulpotomy (C), in terms of a combination of patient and clinical reported outcomes (O), with "tooth survival" as the most critical outcome?
The systematic literature search was conducted in the following electronic databases: OVID, Scopus, PubMed (Including MEDLINE), and Cochrane Central Register of Controlled Trials (CENTRAL) supplemented with Grey literature and hand searching of relevant journals. The English language clinical trials comparing the patient and clinical reported outcomes between partial and full/complete were included. After a structured literature search, two authors independently performed study selection, extracted data and performed a risk of bias assessment; a third reviewer resolved disagreements. As there were only two studies with different exclusion criteria, no meta-analysis was performed and the quality of evidence was assessed by the GRADE approach.
After study selection a total of two randomised clinical trials with a total of 156 teeth were included both for the management of teeth with irreversible pulpitis. There were no studies for asymptomatic teeth or teeth with reversible pulpitis. A "Low" risk of bias was noted for both studies with a high level of overall evidence. A meta-analysis was not carried out due to differences in inclusion criteria between the studies related principally to caries depth. Both studies reported a high rate of clinical success for pulpotomy with a pooled unadjusted success rate for full pulpotomy of 90% and 83% partial pulpotomy of at 1-year; however, no significant difference between the treatments was noted in either study. There was significantly reduced postoperative pain reported in the full pulpotomy group over 1-week compared with the partial pulpotomy in one but not in the other study.
Pulpotomy as a definitive treatment modality is as effective in managing teeth exhibiting signs and symptoms indicative of irreversible pulpitis and challenges the established protocols to manage this condition. Although based on only two RCTs with a limited number of patients, no difference was shown in terms of clinical or radiographic outcome or postoperative pain between groups. Further well designed randomised clinical trials of longer duration are required in this area to improve the evidence available.
There is no consistent difference in patient-reported pain between partial and full pulpotomy at day 7 postoperatively and the clinical success rate was similar after 1 year for both treatment modalities.
牙髓炎可能无痛,也可能表现为轻度至重度疼痛及相关症状。最近有证据表明,对于出现不同症状范围的龋源性牙髓暴露患者,牙髓切断术可有效治疗。
本次系统评价旨在回答以下研究问题:“对于恒牙深龋病变且无症状、可逆性牙髓炎或有不可逆性牙髓炎体征和症状的患者(P),部分牙髓切断术(I)与完全牙髓切断术(C)在患者和临床报告结局(O)的综合方面,以‘牙齿存活’为最关键结局,是否同样有效?”
在以下电子数据库中进行系统文献检索:OVID、Scopus、PubMed(包括MEDLINE)以及Cochrane对照试验中心注册库(CENTRAL),并辅以灰色文献及相关期刊的手工检索。纳入比较部分牙髓切断术与完全/完整牙髓切断术的患者和临床报告结局的英文临床试验。经过结构化文献检索后,两位作者独立进行研究选择、提取数据并进行偏倚风险评估;第三位评审员解决分歧。由于仅有两项研究的排除标准不同,则未进行荟萃分析,证据质量采用GRADE方法评估。
经过研究选择,共纳入两项随机临床试验,总计156颗牙齿用于治疗不可逆性牙髓炎。对于无症状牙齿或可逆性牙髓炎牙齿,未检索到相关研究。两项研究均显示偏倚风险为“低”,总体证据水平较高。由于主要与龋洞深度相关的研究纳入标准存在差异,未进行荟萃分析。两项研究均报告牙髓切断术的临床成功率较高;完全牙髓切断术1年时的汇总未调整成功率为90%,部分牙髓切断术为83%;然而,两项研究均未发现两种治疗方法之间存在显著差异。在一项研究中,完全牙髓切断术组术后1周的疼痛报告较部分牙髓切断术组显著减轻,但另一项研究中未发现此差异。
牙髓切断术作为一种确定性治疗方式,在治疗表现出不可逆性牙髓炎体征和症状的牙齿方面同样有效,并对管理这种情况的既定方案提出了挑战。尽管仅基于两项纳入患者数量有限的随机对照试验,但两组在临床或影像学结局或术后疼痛方面均未显示出差异。该领域需要进一步设计良好的长期随机临床试验,以完善现有证据。
术后第7天,部分牙髓切断术和完全牙髓切断术在患者报告的疼痛方面无一致差异,两种治疗方式1年后的临床成功率相似。