Department of Clinical Pharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Bu-Ali Sina Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Taiwan J Obstet Gynecol. 2024 Sep;63(5):673-678. doi: 10.1016/j.tjog.2024.06.004.
Female sexual dysfunction (FSD) is highly prevalent and can result from hypovitaminosis D. Besides the role of vitamin D in normal bone development, studies showed it could reduce oxidative stress and lipid peroxidation. This prospective study aims to evaluate the relationship between serum vitamin D, testosterone, and oxidative stress levels in women with FSD.
In this cross-sectional study, a total of 40 women with FSD (age range: 18-45 years) were randomly assigned into two groups of intervention and control. In the intervention group, patients received vitamin D 300,000 IU intramuscularly (IM) and then 50,000 IU orally once a week for four weeks. We measured the serum vitamin D, testosterone, and oxidative stress levels, as well as the Female Sexual Function Index (FSFI) at baseline and monthly for three months.
Serum testosterone levels significantly increased in the intervention group at the end of the third month (P = 0.014). Also, FSFI scores significantly improved (P < 0.01) in the intervention group compared to the control group. While there was positive a correlation between serum vitamin D levels with glutathione, total antioxidant capacity (TAC), testosterone, and FSFI score, there was a negative correlation between serum vitamin D levels with malondialdehyde (MDA), protein carbonyl, and nitric oxide.
We witnessed that women with FSD had low serum vitamin D levels. So, modifying serum vitamin D levels must be considered as a treatment option. Moreover, vitamin D supplementation improved testosterone, serum oxidative stress, and sexual function.
女性性功能障碍（FSD）的发病率很高，可能是由于维生素 D 缺乏症引起的。除了维生素 D 在正常骨骼发育中的作用外，研究还表明它可以降低氧化应激和脂质过氧化。本前瞻性研究旨在评估 FSD 女性血清维生素 D、睾酮和氧化应激水平之间的关系。
在这项横断面研究中，总共随机分配了 40 名 FSD 女性（年龄范围：18-45 岁）进入干预组和对照组。在干预组中，患者接受肌内（IM）注射 300,000IU 维生素 D3，然后每周口服 50,000IU 维生素 D3，持续四周。我们在基线和三个月内每月测量血清维生素 D、睾酮和氧化应激水平以及女性性功能指数（FSFI）。
干预组在第三个月末血清睾酮水平显著升高（P=0.014）。此外，与对照组相比，干预组的 FSFI 评分显著改善（P<0.01）。血清维生素 D 水平与谷胱甘肽、总抗氧化能力（TAC）、睾酮和 FSFI 评分呈正相关，而与丙二醛（MDA）、蛋白质羰基和一氧化氮呈负相关。
我们发现 FSD 女性的血清维生素 D 水平较低。因此，应考虑调整血清维生素 D 水平作为治疗选择。此外，维生素 D 补充剂可改善睾酮、血清氧化应激和性功能。
