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小檗碱通过改善肠道微生物群减轻三硝基苯磺酸诱导的小鼠结肠炎。

Berberine attenuates TNBS-induced colitis in mice by improving the intestinal microbiota.

作者信息

Li Chao, Yin Xinxin, Xie Changpeng, Zeng Jin, Song Chuan, Yang Guibin, Zhang Jinglei, Chen Siai, Wei Panjian, Wang Ziyu, Gu Meng, Li Wei, An Juan, Pan Yuanming

机构信息

Department of Gastroenterology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Department of Basic Medical Sciences, Qinghai University Medical College, Xining, China.

出版信息

Front Microbiol. 2024 Aug 29;15:1463005. doi: 10.3389/fmicb.2024.1463005. eCollection 2024.

DOI:10.3389/fmicb.2024.1463005
PMID:39268532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11392431/
Abstract

OBJECTIVE: To investigate the effects of berberine (BBR) as a treatment on intestinal microecological alterations and enteritis in mice produced by TNBS. METHODS: There were seven mice per group: seven in the healthy group (Ctrl), seven in the TNBS-induced enteritis group (TNBS), and seven in the berberine treatment group (BBR). The mice were weighed, slaughtered after 7 days, and subjected to high-throughput intestinal microecological analysis by Illumina, as well as haematological detection and imaging evaluation of colon pathology. RESULTS: The alterations in colon length, immune cell subpopulations, inflammatory factors, and intestinal microecology of mice induced by BBR were refined using a battery of experiments and observations. According to intestinal microecological studies, BBR can increase the number of bacteria, including , , , and . CONCLUSION: BBR has a therapeutic effect on TNBS-induced colitis in mice, which is associated with modifications in immune cell subpopulations and intestinal microecology. It also offers a viable approach as a prospective probiotic (like ) to IBD therapy in clinical settings.

摘要

目的：研究小檗碱（BBR）对三硝基苯磺酸（TNBS）诱导的小鼠肠道微生态改变和肠炎的治疗作用。 方法：每组7只小鼠：健康组（Ctrl）7只、TNBS诱导的肠炎组（TNBS）7只、小檗碱治疗组（BBR）7只。对小鼠称重，7天后处死，采用Illumina进行高通量肠道微生态分析，并进行血液学检测和结肠病理学成像评估。 结果：通过一系列实验和观察，明确了BBR诱导的小鼠结肠长度、免疫细胞亚群、炎症因子和肠道微生态的改变。根据肠道微生态研究，BBR可增加包括[具体细菌种类未给出]、[具体细菌种类未给出]、[具体细菌种类未给出]和[具体细菌种类未给出]在内的细菌数量。 结论：BBR对TNBS诱导的小鼠结肠炎具有治疗作用，这与免疫细胞亚群和肠道微生态的改变有关。它还为临床环境中炎症性肠病（IBD）的治疗提供了一种可行的方法，作为一种潜在的益生菌（如[未明确的类似物]）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/d8c66cf37500/fmicb-15-1463005-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/a71c9bc206f7/fmicb-15-1463005-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/3090cf92d744/fmicb-15-1463005-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/1833343a92f8/fmicb-15-1463005-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/dc448a91a42d/fmicb-15-1463005-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/a301fb6a3101/fmicb-15-1463005-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/0d62ce29dbb3/fmicb-15-1463005-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/e261ca781cbe/fmicb-15-1463005-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/87cc332100a6/fmicb-15-1463005-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/c336b88e4bd9/fmicb-15-1463005-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/d8c66cf37500/fmicb-15-1463005-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/a71c9bc206f7/fmicb-15-1463005-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/3090cf92d744/fmicb-15-1463005-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/1833343a92f8/fmicb-15-1463005-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/dc448a91a42d/fmicb-15-1463005-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/a301fb6a3101/fmicb-15-1463005-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/0d62ce29dbb3/fmicb-15-1463005-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/e261ca781cbe/fmicb-15-1463005-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/87cc332100a6/fmicb-15-1463005-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/c336b88e4bd9/fmicb-15-1463005-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3314/11392431/d8c66cf37500/fmicb-15-1463005-g010.jpg

相似文献

[1]
Berberine attenuates TNBS-induced colitis in mice by improving the intestinal microbiota.

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[2]
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[4]
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[7]
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[8]
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本文引用的文献

[1]
Berberine alleviates concanavalin A-induced autoimmune hepatitis in mice by modulating the gut microbiota.

Hepatol Commun. 2024-3-11

[2]
VEGF and EGFR signaling pathways are involved in the baicalein attenuation of OVA-induced airway inflammation and airway remodeling in mice.

Respir Res. 2024-1-4

[3]
Effect of Extracelluar Vesicles Derived from on Intestinal Barrier in Colitis Mice.

Nutrients. 2023-11-8

[4]
Berberine: An inspiring resource for the treatment of colorectal diseases.

Biomed Pharmacother. 2023-11

[5]
Berberine improves DSS-induced colitis in mice by modulating the fecal-bacteria-related bile acid metabolism.

Biomed Pharmacother. 2023-11

[6]
Babao Dan alleviates gut immune and microbiota disorders while impacting the TLR4/MyD88/NF-кB pathway to attenuate 5-Fluorouracil-induced intestinal injury.

Biomed Pharmacother. 2023-10

[7]
Berberine Reduces Lipid Accumulation in Obesity via Mediating Transcriptional Function of PPARδ.

Int J Mol Sci. 2023-7-18

[8]
Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects.

Acta Pharm Sin B. 2023-5

[9]
Alleviates Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Mice.

Metabolites. 2023-1-28

[10]
Understanding the Connection between Gut Homeostasis and Psychological Stress.

J Nutr. 2023-4

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