Department of Dermatology, Avicenne University Hospital, AP-HP, Sorbonne-Paris-Nord University, Bobigny, France.
French Group of Cutaneous Cancers (Groupe de Cancérologie Cutanée - GCC), France.
Immunotherapy. 2024;16(16-17):1029-1037. doi: 10.1080/1750743X.2024.2399498. Epub 2024 Sep 13.
Immune-mediated sinusitis is poorly described and may easily go undiagnosed. We conducted a retrospective, multicenter, national study focusing on symptomatic immune-mediated sinusitis in patients receiving immune checkpoint inhibitors (ICIs) for melanoma treatment. Twelve patients were included (50% women, median age 58 years). Overall, the paraclinical assessment, the inefficacy of antibiotic/antihistaminic treatment, the improvement of symptoms on immunosuppressants and/or after ICI discontinuation, and the presence of multiple concomitant immune-related adverse-events, suggested a noninfectious etiology. Recognizing this toxicity is imperative for limitation of diagnostic wandering and appropriate treatment. However, additional epidemiological studies are needed to assess its prevalence as a potential immune-related adverse-event, and its prognostic value in patients treated with ICIs.
免疫介导性鼻窦炎描述不佳，容易漏诊。我们进行了一项回顾性、多中心、全国性研究，重点关注接受免疫检查点抑制剂 (ICI) 治疗黑色素瘤的患者出现的有症状免疫介导性鼻窦炎。共纳入 12 名患者（女性占 50%，中位年龄 58 岁）。总的来说，临床检查、抗生素/抗组胺治疗无效、免疫抑制剂治疗后症状改善和/或 ICI 停药后症状改善，以及同时存在多种免疫相关不良事件，提示为非感染性病因。认识到这种毒性对于限制诊断性探索和适当治疗至关重要。然而，需要进一步的流行病学研究来评估其作为潜在免疫相关不良事件的发生率，以及其在接受 ICI 治疗的患者中的预后价值。
