Moolasart Visal, Nitiyanontakij Ravee, Samadchai Srisuda, Srisopha Somkid, Atiburanakul Priyanut, Chottanapund Suthat, Uttayamakul Sumonmal
Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Nonthaburi, Thailand.
Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
Glob Pediatr Health. 2024 Sep 12;11:2333794X241275267. doi: 10.1177/2333794X241275267. eCollection 2024.
We aimed to compare the prevalence of co-infections, pathogens, and factors associated with SARS-CoV-2 acute respiratory infection (ARI) and non-SARS-CoV-2 ARI, among hospitalized children. We conducted an observational cross-sectional study of hospitalized children <15 years with ARI, and lasting respiratory symptoms <14 days, using polymerase chain reaction on nasopharyngeal specimens. Of the 184 children with ARI analyzed, 122 were infected with SARS-CoV-2 and 62 were not. SARS-CoV-2 ARI had a significantly lower rate of co-infection than non-SARS-CoV-2 ARI (2.5% vs14.5%, = .003). SARS-CoV-2 ARI children were significantly associated with a less empirical antibiotics (aOR = 0.09, CI = 0.03-0.21; = .000), more pneumonia (aOR = 5.15, CI = 1.77-14.95; = .003), and more abnormal chest X-ray (aOR = 2.81, CI = 1.38-5.71; = .004). Although SARS-CoV-2 ARI in hospitalized children was associated with pneumonia and abnormal chest x-rays, empirical antibiotics may not be necessary for treating mild to moderate cases.
我们旨在比较住院儿童中与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）急性呼吸道感染（ARI）和非SARS-CoV-2 ARI相关的合并感染、病原体及因素的患病率。我们对15岁以下患有ARI且持续呼吸道症状小于14天的住院儿童进行了一项观察性横断面研究，对鼻咽标本进行聚合酶链反应检测。在分析的184例ARI儿童中，122例感染了SARS-CoV-2，62例未感染。SARS-CoV-2 ARI的合并感染率显著低于非SARS-CoV-2 ARI（2.5%对14.5%，P = 0.003）。SARS-CoV-2 ARI儿童与较少使用经验性抗生素显著相关（调整后比值比[aOR]=0.09，可信区间[CI]=0.03 - 0.21；P = 0.000），更多肺炎（aOR = 5.15，CI = 1.77 - 14.95；P = 0.003），以及更多胸部X线异常（aOR = 2.81，CI = 1.38 - 5.71；P = 0.004）。尽管住院儿童中的SARS-CoV-2 ARI与肺炎和胸部X线异常有关，但对于轻至中度病例可能无需使用经验性抗生素进行治疗。
