Crosier P S, Simpson E J, MacDonald P R
Cell Immunol. 1985 Oct 1;95(1):54-64. doi: 10.1016/0008-8749(85)90294-1.
We describe some aspects of the biology of a suppressor factor (SF) secreted by actively metabolizing and dividing alloantigen-primed T cells which functions by regulating human cytotoxic T-lymphocyte (CTL) activation. The SF functions most effectively during the first 24 hr of CTL activation, while it does not function at the CTL effector stage. Both T cells and adherent cells are capable of absorbing out the biological activity from suppressor factor supernatants. Experiments demonstrated that either fresh adherent cells or the addition of interleukin 2 (IL-2) into the test system could reverse the effects of the SF on CTL activation. These data suggest that the SF could be acting by either indirectly restricting IL-2 availability to proliferating CTLs by limiting adherent cell interleukin 1 (IL-1) secretion or, alternatively, SF acting directly on the IL-2-producing T cells.
我们描述了一种由活跃代谢和分裂的同种异体抗原致敏T细胞分泌的抑制因子（SF）生物学的某些方面，该抑制因子通过调节人细胞毒性T淋巴细胞（CTL）激活发挥作用。SF在CTL激活的最初24小时内作用最为有效，而在CTL效应阶段则不起作用。T细胞和贴壁细胞都能够从抑制因子上清液中吸收生物活性。实验表明，新鲜的贴壁细胞或在测试系统中添加白细胞介素2（IL-2）都可以逆转SF对CTL激活的影响。这些数据表明，SF可能通过限制贴壁细胞白细胞介素1（IL-1）分泌间接限制增殖中的CTL可获得的IL-2，或者SF直接作用于产生IL-2的T细胞。
