托塞米治疗慢性肾脏病相关水肿。

Torsemide in Edema Associated with Chronic Kidney Disease.

机构信息

Director and Consultant Nephrologist, Department of Nephrology, Supreme Kidney Care; Professor, Department of Medicine, Dr Vasantrao Pawar Medical College, Hospital and Research Centre, Maharashtra University of Health Sciences (MUHS), Nashik, Maharashtra, India, Corresponding Author.

Consultant Nephrologist, Transplant Physician, Professor, and Head, Department of Nephrology, NRS Medical College and Hospital, Kolkata, West Bengal, India.

出版信息

J Assoc Physicians India. 2024 Sep;72(9S):27-31. doi: 10.59556/japi.72.0674.

DOI:10.59556/japi.72.0674

PMID:39291570

Abstract

Torsemide is a loop diuretic used to manage edema associated with chronic kidney disease (CKD) and acute kidney injury (AKI). It acts by inhibiting sodium and chloride ions reabsorption in the ascending limb of the loop of Henle, thereby increasing urine output and reducing fluid accumulation. Compared to other diuretics, torsemide has an extended duration of action, higher bioavailability, and its elimination route is primarily through the hepatic route, making it effective in patients with CKD and AKI. Clinical studies indicate that torsemide can improve symptoms of fluid overload and potentially enhance renal function.

摘要

托塞米是一种袢利尿剂，用于治疗慢性肾脏病（CKD）和急性肾损伤（AKI）相关的水肿。它通过抑制升支袢中的钠离子和氯离子重吸收起作用，从而增加尿量并减少液体蓄积。与其他利尿剂相比，托塞米的作用持续时间更长，生物利用度更高，其消除途径主要通过肝脏途径，因此对 CKD 和 AKI 患者有效。临床研究表明，托塞米可以改善液体超负荷的症状，并可能增强肾功能。