自发性高血压和正常血压的Wistar-Kyoto大鼠对乙醇、戊巴比妥和巴比妥的敏感性差异

Differential sensitivity to ethanol, pentobarbital, and barbital in spontaneously hypertensive and normotensive Wistar-Kyoto rats.

作者信息

Khanna J M, Lê A D, Kalant H, Kim C

出版信息

Psychopharmacology (Berl). 1985;86(3):296-301. doi: 10.1007/BF00432217.

Abstract

Ethanol, pentobarbital, and barbital sleep times and blood levels on awakening were determined in female spontaneously hypertensive (SH) and normotensive Wistar-Kyoto (WK) rats. Ethanol-induced sleep times were significantly longer for SH than for WK and blood ethanol concentrations on awakening were significantly lower in SH than in WK rats. By contrast, pentobarbital and barbital sleep times for SH rats were significantly less than for WK rats and barbiturate blood levels at awakening were significantly higher in SH than in WK rats. No differences were observed between SH and WK rats with respect to the disappearance of ethanol, pentobarbital, and barbital from blood and in the apparent volume of distribution of these drugs. These observations suggest differential CNS sensitivity of the SH and WK rats to ethanol and barbiturates and provide additional support for the notion that there exist differences in the modes of acute action of these drugs.

摘要

测定了雌性自发性高血压（SH）大鼠和正常血压的Wistar-Kyoto（WK）大鼠的乙醇、戊巴比妥和巴比妥睡眠时间以及苏醒时的血药浓度。乙醇诱导的睡眠时间SH大鼠明显长于WK大鼠，且SH大鼠苏醒时的血乙醇浓度明显低于WK大鼠。相比之下，SH大鼠的戊巴比妥和巴比妥睡眠时间明显短于WK大鼠，且SH大鼠苏醒时的巴比妥血药浓度明显高于WK大鼠。在乙醇、戊巴比妥和巴比妥从血液中的消失情况以及这些药物的表观分布容积方面，SH大鼠和WK大鼠之间未观察到差异。这些观察结果表明SH大鼠和WK大鼠对乙醇和巴比妥类药物的中枢神经系统敏感性不同，并为这些药物急性作用方式存在差异这一观点提供了额外支持。