Bracale G, Selvetella L, Bernardo B, Scalise E, Bertone L, De Caterina M
Ric Clin Lab. 1985;15 Suppl 1:195-203.
During the last three years we have analyzed, in 94 patients with chronic arterial occlusive disease, in order to assess the hemorheological and hemocoagulative balance, the following parameters: prothrombin time, partial thromboplastin time, antithrombin III, antiplasmin, fibrinogen, factor VIII, erythrocyte sedimentation rate, platelet aggregation, erythrocyte filterability and hematocrit values. The main findings were: in 56 patients the hematocrit value was higher than 44%; Katz index was above normal values in 61.7% of the cases; ATIII showed a trend to lower values; platelet aggregation was increased; no significant variations in comparison to normal values were found in FVIII, antiplasmin levels, prothrombin time and partial thromboplastin time. Erythrocyte filterability values were decreased at a level as lower as more advanced was the clinical stage of the disease. These findings show, in agreement with those of other authors, the presence of hyperviscosity and hypercoagulative state in patients with chronic arterial occlusive disease.
在过去三年中，我们对94例慢性动脉闭塞性疾病患者进行了分析，以评估血液流变学和血液凝固平衡，分析了以下参数：凝血酶原时间、部分凝血活酶时间、抗凝血酶III、抗纤溶酶、纤维蛋白原、因子VIII、红细胞沉降率、血小板聚集、红细胞滤过率和血细胞比容值。主要发现如下：56例患者的血细胞比容值高于44%；61.7%的病例卡茨指数高于正常值；抗凝血酶III呈降低趋势；血小板聚集增加；因子VIII、抗纤溶酶水平、凝血酶原时间和部分凝血活酶时间与正常值相比无显著变化。随着疾病临床分期越严重，红细胞滤过率值越低。与其他作者的研究结果一致，这些发现表明慢性动脉闭塞性疾病患者存在高粘滞血症和高凝状态。
