Department of Pathology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai 200090, PR China.
Department of Pathology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai 200090, PR China.
Cell Signal. 2024 Dec;124:111413. doi: 10.1016/j.cellsig.2024.111413. Epub 2024 Sep 16.
The renin-angiotensin system (RAS) is a crucial factor in chronic kidney disease (CKD) progression, affecting renal function and contributing significantly to renal tissue inflammation and fibrosis. Activation of the classical ACE/Ang II/AT1 axis exacerbates renal damage, while the ACE2/Ang-(1-7)/Mas axis has shown promise in reducing CKD progression in numerous animal models. Recently, the ACE2/Ang-(1-7)/Mas axis has emerged as a promising target for CKD interventions. This review provides a comprehensive review of the pivotal role of this axis in CKD pathogenesis and systematically examines various molecules and pharmaceutical agents targeting this pathway. This review aims to elucidate potential strategies for delaying or halting CKD progression, offering patients more effective treatment options.
肾素-血管紧张素系统（RAS）是慢性肾脏病（CKD）进展的关键因素，影响肾脏功能，并显著导致肾脏组织炎症和纤维化。经典的 ACE/Ang II/AT1 轴的激活会加重肾脏损伤，而 ACE2/Ang-(1-7)/Mas 轴在许多动物模型中已显示出可降低 CKD 进展的潜力。最近，ACE2/Ang-(1-7)/Mas 轴已成为 CKD 干预的有前途的靶点。本综述全面回顾了该轴在 CKD 发病机制中的关键作用，并系统地研究了针对该途径的各种分子和药物制剂。本综述旨在阐明延迟或阻止 CKD 进展的潜在策略，为患者提供更有效的治疗选择。
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