Cold G E, Eskesen V, Eriksen H, Amtoft O, Madsen J B
Acta Anaesthesiol Scand. 1985 Jul;29(5):490-4. doi: 10.1111/j.1399-6576.1985.tb02240.x.
In 14 patients with supratentorial cerebral tumours with midline shift below 10 mm, CBF and CMRO2 were measured (Kety & Schmidt) during craniotomy. The anaesthesia was continuous etomidate infusion supplemented with nitrous oxide and fentanyl. The patients were divided into two groups. In Group 1 etomidate infusion of 30 micrograms kg-1 min-1 was used throughout the anaesthesia, and CBF and CMRO2 were measured twice. In this group CMRO2 (means +/- s.d.) averaged 2.31 +/- 0.43 ml O2 100 g-1 min-1 70 min after induction and 2.21 +/- 0.38 ml O2 100 g-1 min-1 130 min after induction. In Group 2 the etomidate infusion was increased from 30 to 60 micrograms kg-1 min-1 after the first study and a significant fall in CMRO2 from 2.52 +/- 0.56 to 1.76 +/- 0.40 ml O2 100 g-1 min-1 was found. Simultaneously, a significant fall in CBF was observed. The CO2 reactivity was preserved during anaesthesia.
在14例幕上脑肿瘤且中线移位小于10mm的患者中，在开颅手术期间（采用凯蒂和施密特法）测量了脑血流量（CBF）和脑氧代谢率（CMRO2）。麻醉采用持续输注依托咪酯，并辅以氧化亚氮和芬太尼。患者被分为两组。在第1组中，整个麻醉过程中依托咪酯输注速率为30微克/千克·分钟，CBF和CMRO2测量了两次。在该组中，诱导后70分钟时CMRO2（平均值±标准差）平均为2.31±0.43毫升O2/100克·分钟，诱导后130分钟时为2.21±0.38毫升O2/100克·分钟。在第2组中，首次研究后依托咪酯输注速率从30微克/千克·分钟增加到60微克/千克·分钟，发现CMRO2从2.52±0.56显著降至1.76±0.40毫升O2/100克·分钟。同时，观察到CBF显著下降。麻醉期间二氧化碳反应性得以保留。
