Battistella Aurora, Linger Morgan, Nguyen Anh Thy, Madukwe David, Roy-Chaudhury Prabir, Tan Wei
Paul M. Rady Mechanical Engineering, University of Colorado at Boulder, Boulder, CO, United States.
Department of Biomedical Engineering, University of Colorado at Boulder, Boulder, CO, United States.
Front Bioeng Biotechnol. 2024 Sep 4;12:1448186. doi: 10.3389/fbioe.2024.1448186. eCollection 2024.
This review presents a comprehensive analysis of vascular access in hemodialysis, focusing on the current modalities, their associated challenges, and recent technological advancements. It closely examines the status of three primary types of vascular access: arteriovenous fistulas, arteriovenous grafts, and central venous catheters. The review delves into the complications and pathologies associated with these access types, emphasizing the mechanobiology-related pathogenesis of arteriovenous access. Furthermore, it explores recent clinical trials, biomaterials, and device innovations, highlighting novel pharmaceutical approaches, advanced materials, device designs, and cutting-edge technologies aimed at enhancing the efficacy, safety, and longevity of vascular access in hemodialysis. This synthesis of current knowledge and emerging trends underscores the dynamic evolution of vascular access strategies and their critical role in improving patient care in hemodialysis.
本综述对血液透析中的血管通路进行了全面分析，重点关注当前的方式、其相关挑战以及近期的技术进展。它仔细研究了三种主要血管通路类型的现状：动静脉内瘘、动静脉移植物和中心静脉导管。该综述深入探讨了与这些通路类型相关的并发症和病理情况，强调了动静脉通路的机械生物学相关发病机制。此外，它还探索了近期的临床试验、生物材料和设备创新，突出了旨在提高血液透析中血管通路的疗效、安全性和使用寿命的新型药物方法、先进材料、设备设计和前沿技术。当前知识与新趋势的综合强调了血管通路策略的动态演变及其在改善血液透析患者护理方面的关键作用。
