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肾移植结果:当良好结果下降时,有可能改善吗?

Kidney transplantation outcomes: Is it possible to improve when good results are falling down?

作者信息

Gonzalez Fernando M, Gonzalez Cohens Francisca Del Rocío

机构信息

Department of Nephrology, Faculty of Medicine, Universidad de Chile, Santiago 7500922, Chile.

Web Intelligence Centre, Faculty of Physics and Mathematical Sciences, Universidad de Chile, Santiago 8370397, Chile.

出版信息

World J Transplant. 2024 Sep 18;14(3):91214. doi: 10.5500/wjt.v14.i3.91214.

DOI:10.5500/wjt.v14.i3.91214
PMID:39295975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11317855/
Abstract

Famure describe that close to 50% of their patients needed early or very early hospital readmissions after their kidney transplantation. As they taught us the variables related to those outcomes, we describe eight teaching capsules that may go beyond what they describe in their article. First two capsules talk about the ideal donors and recipients we should choose for avoiding the risk of an early readmission. The third and fourth capsules tell us about the reality of cadaveric donors and recipients with comorbidities, and the way transplant physicians should choose them to maximize survival. Fifth capsule shows that any mistake can result in an early readmission, and thus, in poorer outcomes. Sixth capsule talks about economic losses of early readmissions, cost-effectiveness of transplantation, and how to improve outcomes and reduce costs by managing a risky patient-portfolio. Seventh capsule argues about knowing your risk behavior to better manage your portfolio; and Eighth capsule about the importance of the center experience in transplanting complex patients. We finish with some lessons of the importance of the transplantation process and the collaboration with other disciplines in order to prevent the conditions that lead to early readmissions.

摘要

法穆尔指出,他们近50%的肾移植患者在术后需要早期或极早期再次入院。在他们向我们介绍了与这些结果相关的变量后,我们阐述了八个教学要点,其内容可能超出了他们文章所描述的范围。前两个要点讨论了为避免早期再次入院风险我们应选择的理想供体和受体。第三和第四个要点讲述了尸体供体和患有合并症受体的实际情况,以及移植医生应如何选择他们以最大化生存率。第五个要点表明任何失误都可能导致早期再次入院,进而导致更差的结果。第六个要点讨论了早期再次入院的经济损失、移植的成本效益,以及如何通过管理高风险患者组合来改善结果并降低成本。第七个要点主张了解自身风险行为以更好地管理患者组合;第八个要点阐述了中心经验在移植复杂患者中的重要性。我们最后总结了移植过程的重要性以及与其他学科合作以预防导致早期再次入院情况的一些经验教训。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bc0/11317855/a6b150eb2ca9/91214-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bc0/11317855/a6b150eb2ca9/91214-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bc0/11317855/a6b150eb2ca9/91214-g001.jpg

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本文引用的文献

1
Outcomes of early hospital readmission after kidney transplantation: Perspectives from a Canadian transplant centre.肾移植后早期再次入院的结局:来自加拿大一家移植中心的观点
World J Transplant. 2023 Dec 18;13(6):357-367. doi: 10.5500/wjt.v13.i6.357.
2
Characterization of Transplant Center Decisions to Allocate Kidneys to Candidates With Lower Waiting List Priority.描述移植中心决定将肾脏分配给等候名单优先级较低的候选人的情况。
JAMA Netw Open. 2023 Jun 1;6(6):e2316936. doi: 10.1001/jamanetworkopen.2023.16936.
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What are the short-term annual cost savings associated with kidney transplantation?
肾移植相关的短期年度成本节约情况如何?
Cost Eff Resour Alloc. 2022 May 3;20(1):20. doi: 10.1186/s12962-022-00355-2.
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OPTN/SRTR 2020 Annual Data Report: Kidney.OPTN/SRTR 2020 年度数据报告:肾脏。
Am J Transplant. 2022 Mar;22 Suppl 2:21-136. doi: 10.1111/ajt.16982.
5
Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients.验证一种生存获益估算工具在欧洲肾移植受者队列中的适用性。
Sci Rep. 2020 Oct 13;10(1):17109. doi: 10.1038/s41598-020-74295-3.
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Cost-effectiveness of Deceased-donor Renal Transplant Versus Dialysis to Treat End-stage Renal Disease: A Systematic Review.已故供体肾移植与透析治疗终末期肾病的成本效益:一项系统评价
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Validation of the Kidney Donor Profile Index (KDPI) to assess a deceased donor's kidneys' outcome in a European cohort.验证 Kidney Donor Profile Index(KDPI)在欧洲队列中评估已故供体肾脏结局的能力。
Sci Rep. 2019 Aug 2;9(1):11234. doi: 10.1038/s41598-019-47772-7.
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Moving boundaries--the Nightingale twins and transplantation science.变动的边界——南丁格尔双胞胎与移植科学
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10
'Old-for-old'--new strategies for renal transplantation.“老年供老年”——肾移植的新策略
Nephrol Dial Transplant. 2007 Feb;22(2):336-41. doi: 10.1093/ndt/gfl637. Epub 2006 Dec 5.