Spring Alexander M, Gjelaj Christiana, Madan Shivank, Patel Snehal R, Saeed Omar, Murthy Sandhya, Rochlani Yogita, Sims Daniel B, Vukelic Sasha, Forest Stephen J, Borgi Jamil F, Goldstein Daniel J, Jorde Ulrich P
Montefiore-Einstein Center for Heart and Vascular Care, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, United States.
Division of Cardiothoracic Surgery, Tulane University, New Orleans, LA 70112, United States.
World J Transplant. 2024 Sep 18;14(3):92721. doi: 10.5500/wjt.v14.i3.92721.
Despite a record setting number of heart transplants performed annually, the national donor shortage continues to plague transplant teams across the United States. Here we describe the barriers to adaptation of numerous "non-traditional" orthotopic heart transplant donor characteristics including donors with hepatitis C virus, those meeting criteria for donation after cardiac death, donors with coronavirus disease 19 infection, donors with the human immunodeficiency virus, and grafts with left ventricular systolic dysfunction. Our center's objective was to increase our transplant volume by expanding our donor pool from "traditional" donors to these "non-traditional" donors. We detail how medical advances such as certain laboratory studies, pharmacologic interventions, and organ care systems have allowed our center to expand the donor pool thereby increasing transplantation volume without adverse effects on outcomes.
尽管每年进行的心脏移植数量创下纪录，但全国性的供体短缺问题仍继续困扰着美国各地的移植团队。在此，我们描述了众多“非传统”原位心脏移植供体特征在适应性方面存在的障碍，这些特征包括丙型肝炎病毒感染者、符合心源性死亡后捐赠标准者、新型冠状病毒肺炎感染者、人类免疫缺陷病毒感染者以及左心室收缩功能障碍的移植物。我们中心的目标是通过将供体库从“传统”供体扩展到这些“非传统”供体来增加移植量。我们详细阐述了某些实验室研究、药物干预和器官护理系统等医学进展如何使我们中心得以扩大供体库，从而增加移植量，同时又不对结果产生不利影响。
