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主要决定因素的幸福感在患有中轴型脊柱关节炎患者:2 年随访。

Major Determinants of Well-Being in Patients With Axial Spondyloarthritis: 2 Year Follow-Up.

机构信息

Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Izmir Katip Celebi University, Izmir, Turkey.

Faculty of Health Science, Department of Physiotherapy and Rehabilitation, Izmir Katip Celebi University, Izmir, Turkey.

出版信息

Musculoskeletal Care. 2024 Sep;22(3):e1942. doi: 10.1002/msc.1942.

DOI:10.1002/msc.1942
PMID:39298026
Abstract

OBJECTIVES

Bath Ankylosing Spondylitis Patient Global Score (BAS-G) is a uni-dimensional scale that enables patients to evaluate the effects of their illness on their health. The aim of this study was to determine the impact of disease related outcomes on the BAS-G scores in patients with axSpA.

METHODS

A total of 309 patients (56.6% of whom were male, mean age 44 ± 11) were included in the study. Socio-demographic characteristics (age, sex and education level) and clinical characteristics such as disease activity (BASDAI and CRP), spinal mobility (BASMI), functional status (BASFI), radiographic structural damage (mSASS, mNY, and BASRI-hip), and health related quality of life (SF-36 and ASQoL) of the patients were recorded at baseline. In addition, BASDAI total and each item score, BASFI, BAS-G, and CRP levels were collected at 6, 12, and 24 months.

RESULTS

Female patients had significantly higher BAS-G scores (p = 0.037). Baseline BASDAI total score (p < 0.001) and all BASDAI item scores (p < 0.001 for each item), BASFI total score (p < 0.001), ASQoL total score (p < 0.001), and SF-36 PCS sum-score (p < 0.001) were moderately/highly correlated with BAS-G. Multivariate analysis revealed that back pain (BASDAI Q2) (p < 0.001) and the severity of morning stiffness (BASDAI Q5) (p < 0.001) were the main determinants of BAS-G in patients with axSpA. In 2-year follow-up, BASDAI Q1, BASDAI Q5, and BASFI scores were independent determinants of BAS-G in patients with axSpA.

CONCLUSION

According to the results of the present study, patients with axSpA mainly rely on morning stiffness and back pain to determine their global health status. Moreover, fatigue, severity of morning stiffness and function are the determinants of BAS-G during follow-up.

摘要

目的

Bath 强直性脊柱炎患者整体评分(BAS-G)是一个一维的量表,使患者能够评估疾病对其健康的影响。本研究的目的是确定疾病相关结局对 axSpA 患者 BAS-G 评分的影响。

方法

共纳入 309 例患者(56.6%为男性,平均年龄 44±11 岁)。记录患者的社会人口学特征(年龄、性别和教育水平)和临床特征,如疾病活动度(BASDAI 和 CRP)、脊柱活动度(BASMI)、功能状态(BASFI)、放射学结构损伤(mSASS、mNY 和 BASRI-hip)和健康相关生活质量(SF-36 和 ASQoL)。此外,还在基线时收集了 BASDAI 总分和各项目评分、BASFI、BAS-G 和 CRP 水平,在 6、12 和 24 个月时进行了收集。

结果

女性患者的 BAS-G 评分明显较高(p=0.037)。基线 BASDAI 总分(p<0.001)和所有 BASDAI 项目评分(p<0.001)、BASFI 总分(p<0.001)、ASQoL 总分(p<0.001)和 SF-36 PCS 总分(p<0.001)与 BAS-G 呈中度/高度相关。多变量分析显示,背痛(BASDAI Q2)(p<0.001)和晨僵严重程度(BASDAI Q5)(p<0.001)是 axSpA 患者 BAS-G 的主要决定因素。在 2 年随访中,BASDAI Q1、BASDAI Q5 和 BASFI 评分是 axSpA 患者 BAS-G 的独立决定因素。

结论

根据本研究结果,axSpA 患者主要依靠晨僵和背痛来确定其整体健康状况。此外,疲劳、晨僵严重程度和功能是 BAS-G 在随访期间的决定因素。

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