1型发作性睡病患者中焦虑与抑郁症状、自杀念头及绝望感的共现情况。

Co-occurrence of anxiety and depressive symptoms, suicidal thoughts, and hopelessness in patients with narcolepsy type 1.

作者信息

Biscarini Francesco, Bassi Chiara, Menchetti Marco, Zenesini Corrado, Baldini Valentina, Franceschini Christian, Varallo Giorgia, Antelmi Elena, Vignatelli Luca, Pizza Fabio, Plazzi Giuseppe, Ingravallo Francesca

机构信息

Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy; IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy.

Department of Human Sciences, University of Verona, Verona, Italy.

出版信息

Sleep Med. 2024 Dec;124:141-145. doi: 10.1016/j.sleep.2024.09.023. Epub 2024 Sep 16.

DOI:10.1016/j.sleep.2024.09.023

PMID:39298876

Abstract

OBJECTIVE

To assesses the prevalence and co-occurrence of anxiety, depressive symptoms, suicidal thoughts, and hopelessness in patients with narcolepsy type 1 (NT1).

PATIENTS/METHODS: In this cross-sectional study, 127 patients with NT1 (mean age 38.2 ± 15.5 years, 53.5 % female) and 131 controls (mean age 37.4 ± 14.3 years, 59.5 % female) matched for age, sex, and education, filled in the following validated questionnaires: Beck Depression Inventory-II (BDI), State-Trait Anxiety Inventory (STAI), and Beck Hopelessness Scale (BHS). Comparisons between groups and multivariable logistic regression analyses were performed.

RESULTS

Patients with NT1 presented significantly higher scores in BDI, suicidal thoughts (BDI-item-9), STAI-trait, STAI-state, and BHS than controls. Adjusted for age, sex, and educational level, NT1 was significantly associated with depressive symptoms (BDI≥13; OR 3.23, 95%CI 1.71-6.10), trait anxiety symptoms (STAI-trait≥38; OR 1.91, 95%CI 1.14-3.21), co-occurrence of BDI≥13 with STAI-trait≥38 (OR 2.72, 95%CI 1.47-5.05), and with STAI-state≥38 (OR 2.24, 95%CI 1.17-4.30), and moderate to severe hopelessness (BHS≥9; OR 2.95, 95%CI 1.55-5.63).

CONCLUSIONS

Patients with NT1 present a multidimensional psychiatric burden and comorbidity between symptoms of depression and anxiety and suicidal thoughts, a concern that deserves tailored interventions.

摘要

目的

评估1型发作性睡病（NT1）患者焦虑、抑郁症状、自杀念头及绝望情绪的患病率和共现情况。

患者/方法：在这项横断面研究中，127例NT1患者（平均年龄38.2±15.5岁，53.5%为女性）和131名对照者（平均年龄37.4±14.3岁，59.5%为女性），在年龄、性别和教育程度上进行匹配，填写以下经过验证的问卷：贝克抑郁量表第二版（BDI）、状态-特质焦虑量表（STAI）和贝克绝望量表（BHS）。进行了组间比较和多变量逻辑回归分析。

结果

NT1患者在BDI、自杀念头（BDI第9项）、STAI特质、STAI状态和BHS上的得分显著高于对照者。在对年龄、性别和教育水平进行调整后，NT1与抑郁症状（BDI≥13；比值比3.23，95%置信区间1.71 - 6.10）、特质焦虑症状（STAI特质≥38；比值比1.91，95%置信区间1.14 - 3.21）、BDI≥13与STAI特质≥38的共现情况（比值比2.72，95%置信区间1.47 - 5.05）、以及与STAI状态≥38的共现情况（比值比2.24，95%置信区间1.17 - 4.30），以及中度至重度绝望情绪（BHS≥9；比值比2.95，95%置信区间1.55 - 5.63）显著相关。