Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Division of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Am Heart J. 2024 Dec;278:170-180. doi: 10.1016/j.ahj.2024.09.002. Epub 2024 Sep 17.
With the advent of novel chemotherapy, survival of patients with cancer has improved. However, people with cancer have an increased risk of heart failure (HF). Conversely, HF-related mortality may undermine survival among people with cancer. We aim to analyze the trends of mortality in people with HF and cancer in the adult US population.
We conducted an examination of death certificates sourced from the CDC WONDER (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) database, from the years 1999 to 2020. Mortality in adults with HF and cancer was assessed. Age-adjusted mortality rates (AAMRs) per 100,000 persons and annual percent change were reported.
Between 1999 and 2020, 621,783 deaths occurred from HF in people with cancer. The AAMR declined from 16.4 in 1999 to 11.9 in 2017, after which an increase to 14.5 was observed in 2020. Men had consistently higher overall AAMR as compared to women (men = 18.1 vs women = 9.9). Similar AAMR was observed between non-Hispanic (NH) Blacks/African Americans (13.9) and NH Whites (13.3), with lower in American Indian/Alaska Native (9.6) and Hispanics (7.4). Asian/Pacific Islanders reported the lowest AAMR (5.7). The Midwestern region reported the highest AAMR (14.8). We observed the highest AAMR amongst the older population (61.4).
The mortality rates of people with HF and cancer are increasing in the adult U.S.
This underscores the need for increased screening, aggressive management, and subsequent surveillance of people at risk or with manifested HF in people with cancer.
随着新型化疗药物的出现，癌症患者的生存率得到了提高。然而，癌症患者患心力衰竭（HF）的风险增加。相反，HF 相关死亡率可能会降低癌症患者的生存率。我们旨在分析美国成年人群中 HF 和癌症患者的死亡率趋势。
我们对 1999 年至 2020 年期间 CDC WONDER（疾病控制与预防中心广泛在线数据用于流行病学研究）数据库中的死亡证明进行了检查。评估了患有 HF 和癌症的成年人的死亡率。报告了每 10 万人的年龄调整死亡率（AAMR）和年百分比变化。
1999 年至 2020 年间，有 621,783 人死于癌症患者的 HF。AAMR 从 1999 年的 16.4 降至 2017 年的 11.9，之后在 2020 年观察到上升至 14.5。男性的总体 AAMR 始终高于女性（男性 = 18.1，女性 = 9.9）。非西班牙裔（NH）黑人和非裔美国人（13.9）和 NH 白人（13.3）之间的 AAMR 相似，美洲印第安人/阿拉斯加原住民（9.6）和西班牙裔（7.4）较低。亚裔/太平洋岛民报告的 AAMR 最低（5.7）。中西部地区报告的 AAMR 最高（14.8）。我们观察到年龄较大人群的 AAMR 最高（61.4）。
美国成年人中 HF 和癌症患者的死亡率正在上升。
这突显出需要增加对有风险或患有 HF 的癌症患者的筛查、积极治疗和随后监测。
