Peschanski M, Poingt J P, Roudier F, Besson J M
C R Acad Sci III. 1985;301(3):83-8.
30 days after kainic acid injection into the rat ventrobasal thalamus, lemniscal afferents were labeled using wheat-germ agglutinin conjugated to HRP. They appeared considerably swollen in the area where neuronal post-synaptic targets had been eliminated. Electron microscopic analysis of the lesioned tissue revealed the presence of large profiles containing numerous organelles, particularly smooth endoplasmic reticulum, and giving rise to thin excrescences filled with neurofilaments. Since these morphological features are typical of regenerating "growth cones", we conclude that afferent terminals deprived of their post-synaptic targets undergo morphological changes preparing them for new synapses.
在向大鼠腹侧基底丘脑注射海藻酸30天后，使用与辣根过氧化物酶（HRP）偶联的麦胚凝集素标记lemniscal传入神经。在神经元突触后靶点已被消除的区域，它们显得明显肿胀。对损伤组织的电子显微镜分析显示，存在含有大量细胞器的大轮廓，特别是滑面内质网，并产生充满神经丝的细突起。由于这些形态学特征是再生“生长锥”的典型特征，我们得出结论，被剥夺突触后靶点的传入终末会发生形态学变化，为形成新突触做好准备。
