Tsao Chia-Wen, Yang Zi-Yi
Department of Mechanical Engineering, National Central University, No. 300, Zhongda Rd., Zhongli District, Taoyuan City 320, Taiwan.
Department of Medical Research, Cathay General Hospital, No. 280, Renai Rd. Sec. 4, Taipei City, 106, Taiwan.
Lab Chip. 2024 Nov 19;24(23):5184-5192. doi: 10.1039/d4lc00550c.
Surface-enhanced Raman spectroscopy (SERS) is a widely used analytical technique known for its high sensitivity and broad applicability. Despite its potential, SERS faces challenges related to detection sensitivity and reproducibility. This study proposes an innovative method to enhance SERS performance by employing water microdroplets as optical lenses on localized silver nanoparticle-decorated porous silicon (LocAg-PS) substrates. The hydrophobic nature of the LocAg-PS substrate not only ensures precise positioning of the microdroplet lenses on the silver nanoparticle grafted pad (AgNP pad) but also forms a plano-convex-like microdroplet lens for the focusing of the excitation laser and the collection of scattered light. Experimental results demonstrate that using microdroplet lenses enhances the SERS signal intensity and reproducibility, providing a rapid and cost-effective solution for advanced SERS analysis.
表面增强拉曼光谱（SERS）是一种广泛应用的分析技术，以其高灵敏度和广泛适用性而闻名。尽管具有潜力，但SERS在检测灵敏度和重现性方面面临挑战。本研究提出了一种创新方法，通过在局部银纳米颗粒修饰的多孔硅（LocAg-PS）基底上使用水微滴作为光学透镜来提高SERS性能。LocAg-PS基底的疏水性不仅确保微滴透镜在银纳米颗粒接枝垫（AgNP垫）上的精确定位，还形成了类似平凸透镜的微滴透镜，用于激发激光的聚焦和散射光的收集。实验结果表明，使用微滴透镜可增强SERS信号强度和重现性，为先进的SERS分析提供了一种快速且经济高效的解决方案。
