胃食管反流病与喉部疾病之间的关联：真实世界证据

Association Between Gastroesophageal Reflux Disease and Laryngeal Disorders: Real-World Evidence.

作者信息

Lee I-Yun, Kuo Yu-Jen, Wu Ching-Yuan, Yang Yao-Hsu, Shih Wei-Tai, Yang Pei-Rung, Chen Ko-Jung, Tsai Yao-Te, Tsai Ming-Shao, Chang Geng-He, Yang Ming-Yu, Hsu Cheng-Ming

机构信息

Department of Chinese Medicine, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.

School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

出版信息

Otolaryngol Head Neck Surg. 2025 Jan;172(1):208-213. doi: 10.1002/ohn.980. Epub 2024 Sep 20.

DOI:10.1002/ohn.980

PMID:39302108

Abstract

OBJECTIVE

The association between gastroesophageal reflux disease (GERD) and laryngeal disorders remains debatable, although it has been the focus of extensive clinical and laboratory research. We conducted this study to obtain evidence on the association.

STUDY DESIGN

Population-based cohort study.

SETTING

Taiwan National Health Insurance Research Database (NHIRD).

METHODS

Using data from Taiwan's NHIRD (January 2000 to December 2018), we performed a population-based analysis to estimate the risk of laryngeal disorders in patients with GERD and those without GERD.

RESULTS

The GERD and non-GERD cohorts comprised 176,319 and 705,276 patients, respectively. The cohorts were matched at a ratio of 1:4 based on sex, age, urbanization level, and income level. The risk of laryngeal disorders was higher in the GERD cohort than in the non-GERD cohort (adjusted hazard ratio: 1.64; 95% confidence interval: 1.61-1.67).

CONCLUSION

This study is the first to use population data for identifying the association between GERD and laryngeal disorders for real-world findings. Our population-based analysis indicates that patients with GERD have an elevated risk of laryngeal disorders.

摘要