Department of Neurosurgery, First People's Hospital of Jiashan County, Jiashan, Zhejiang 314100, China.
Department of Neurosurgery, Second People's Hospital of Jiashan County, Jiashan, Zhejiang 314102, China.
Clin Neurol Neurosurg. 2024 Nov;246:108557. doi: 10.1016/j.clineuro.2024.108557. Epub 2024 Sep 16.
The Platelet-to-Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR) are established biomarkers that are associated with the severity, progression, and fatality of diseases. This study aimed to determine their predictive value for the occurrence of stress ulcers (SU) following surgery for acute cerebral hemorrhage.
Retrospective data from 210 patients with acute cerebral hemorrhage hospitalized between June 2020 and March 2023 were analyzed. Patients were categorized into two groups based on the occurrence of SU post-surgery: the SU group (42 patients) and the non-SU group (168 patients). Clinical characteristics of both groups were compared, and a multivariate logistic regression was conducted to identify independent risk factors for SU. The study evaluated the predictive value of NLR and PLR, individually and in combination, for predicting SU using Receiver Operating Characteristic (ROC) curves.
We observed significant differences between the SU and non-SU groups in several parameters, including GCS score, absolute neutrophils, NLR, PLR, postoperative tracheotomy, and intracranial infection (P < 0.05). Our multivariate logistic regression analysis identified four independent risk factors for SU in patients undergoing surgery for acute cerebral hemorrhage: GCS score, NLR, PLR, and fasting blood glucose (P < 0.05). Furthermore, ROC analysis demonstrated that the combination of NLR and PLR exhibited the highest AUC, sensitivity, and specificity in predicting SU following surgery for acute cerebral hemorrhage (P < 0.001), with values of 0.864 (95 % CI: 0.776-0.953), 0.778 (95 % CI: 0.658-0.899), and 0.941 (95 % CI: 0.889-0.993) respectively.
This study highlighted the combined application of PLR and NLR as a significant predictor of SU in patients post-acute cerebral hemorrhage surgery.
血小板与淋巴细胞比值（PLR）和中性粒细胞与淋巴细胞比值（NLR）是与疾病的严重程度、进展和死亡率相关的已确立的生物标志物。本研究旨在确定它们对急性脑出血手术后应激性溃疡（SU）发生的预测价值。
回顾性分析了 2020 年 6 月至 2023 年 3 月期间住院的 210 例急性脑出血患者的数据。根据手术后是否发生 SU，将患者分为两组：SU 组（42 例）和非-SU 组（168 例）。比较两组的临床特征，并进行多变量 logistic 回归分析，以确定 SU 的独立危险因素。该研究使用接收者操作特征（ROC）曲线评估 NLR 和 PLR 单独和联合预测 SU 的预测价值。
我们观察到 SU 组和非-SU 组在 GCS 评分、绝对中性粒细胞数、NLR、PLR、术后气管切开术和颅内感染等几个参数方面存在显著差异（P < 0.05）。多变量 logistic 回归分析确定了急性脑出血手术患者发生 SU 的四个独立危险因素：GCS 评分、NLR、PLR 和空腹血糖（P < 0.05）。此外，ROC 分析表明，NLR 和 PLR 联合预测急性脑出血手术后 SU 的 AUC、敏感性和特异性最高（P < 0.001），分别为 0.864（95%CI：0.776-0.953）、0.778（95%CI：0.658-0.899）和 0.941（95%CI：0.889-0.993）。
本研究强调了 PLR 和 NLR 的联合应用是急性脑出血手术后 SU 的重要预测指标。
