School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom.
School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom.
J Affect Disord. 2025 Jan 1;368:503-512. doi: 10.1016/j.jad.2024.09.106. Epub 2024 Sep 18.
Anhedonia, the loss of interest and pleasure, is a core symptom of depression that is resistant to treatment. Anhedonic young people describe a weakened sense of self and reduced meaning in life. Knowing if these experiences predict anhedonia could reveal novel targets for intervention development.
We recruited young people (N = 429, mean age: 20 years) with a range of depression scores. Using path analysis, we examined anhedonia, sense of self, meaning in life, and prosocial behaviours cross-sectionally and longitudinally at ∼5-month follow-up (N = 160).
Cross-sectionally, sense of self (β =. 81, p < .001) and prosocial behaviours (β = 0.37, p < .001) had direct effects on meaning in life, and meaning in life had a direct effect on anhedonia (β = -0.11, p < .001). Sense of self (β = -0.09, p < .001) and prosocial behaviours (β = -0.04, p < .001) had indirect effects on anhedonia, mediated by meaning in life. In the longitudinal analysis, sense of self at T1 had a direct effect on meaning in life at T2 (β = 0.36, p < .01) and an indirect effect on anhedonia at T2 (β = -0.05, p < .01), mediated by meaning in life.
Approximately 70 % of the participants were female. Future studies should include equal numbers of males and females.
We provide novel evidence that targeting meaning in life, sense of self, or prosocial behaviours in psychotherapeutic interventions could be effective in alleviating anhedonia.
快感缺失,即兴趣和愉悦感的丧失,是一种对治疗有抗性的抑郁核心症状。快感缺失的年轻人会描述自我意识减弱和生活意义感降低。了解这些体验是否能预测快感缺失,可以为干预措施的发展揭示新的目标。
我们招募了具有不同抑郁评分的年轻人(N=429,平均年龄:20 岁)。使用路径分析,我们在大约 5 个月的随访中(N=160)同时对快感缺失、自我意识、生活意义感和亲社会行为进行了横向和纵向研究。
横向研究显示,自我意识(β=.81,p<0.001)和亲社会行为(β=0.37,p<0.001)对生活意义感有直接影响,生活意义感对快感缺失有直接影响(β=-0.11,p<0.001)。自我意识(β=-0.09,p<0.001)和亲社会行为(β=-0.04,p<0.001)对快感缺失有间接影响,这种影响通过生活意义感起中介作用。在纵向分析中,T1 时的自我意识对 T2 时的生活意义感有直接影响(β=0.36,p<0.01),对 T2 时的快感缺失有间接影响(β=-0.05,p<0.01),这种影响通过生活意义感起中介作用。
大约 70%的参与者为女性。未来的研究应该包括等量的男性和女性。
我们提供了新的证据,表明在心理治疗干预中针对生活意义感、自我意识或亲社会行为进行干预可能会有效缓解快感缺失。