Orthopedics and Orthopedic Oncology, Department of Surgery, Oncology and Gastroenterology (DiSCOG), University-Hospital of Padova, Padova, Italy.
Centre for Mechanics of Biological Materials, University of Padova, Padova, Italy.
Foot Ankle Int. 2024 Nov;45(11):1184-1197. doi: 10.1177/10711007241268082. Epub 2024 Sep 21.
Diabetic foot is one of the major complications of diabetes, affecting 15% of patients with diabetes. This study aims to evaluate and compare the clinical and radiographic outcomes of patients with diabetes affected by forefoot plantar preulcerative or ulcerative lesions who have undergone minimally invasive distal metatarsal diaphyseal osteotomy (MIS-DMDO) to assess its efficacy in the prevention and treatment of chronic plantar diabetic foot ulcers (CPDFUs).
The study included 60 patients, 38 with preulcers and 22 with ulcers, with at least 2 years of clinical and radiologic follow-up. Clinical outcomes were assessed using the European Foot and Ankle Society (EFAS) score, the Foot Function Index (FFI), and the Manchester-Oxford Foot Questionnaire (MOXFQ). The radiographic evaluation was performed according to the Maestro criteria.
Both groups improved in clinical and radiologic outcomes when comparing baseline measurements to those at the final follow-up. There were no statistical differences between preulcer and ulcer groups in terms of both clinical and radiologic outcomes, with the only exception being FFI, which was lower in the preulcerative group. In multivariate analysis, gender and glycated hemoglobin (HbA) were predictors of better outcomes. Specifically, FFI and MOXFQ ( < .05) exhibited larger improvements in females, while Maestro 1 and 2 were better in patients with lower HbA ( < .05). All patients were considered healed at the final follow-up.
Carefully performed minimally invasive distal metatarsal diaphyseal osteotomy can be an effective approach to the care of impending or chronically present plantar diabetic foot ulcers.
糖尿病足是糖尿病的主要并发症之一,影响 15%的糖尿病患者。本研究旨在评估和比较接受微创远端跖骨干骺端截骨术(MIS-DMDO)治疗的糖尿病前足跖侧溃疡前期或溃疡患者的临床和影像学结果,以评估其在预防和治疗慢性足底糖尿病足溃疡(CPDFU)方面的疗效。
本研究纳入了 60 名患者,其中 38 名患有前溃疡,22 名患有溃疡,至少有 2 年的临床和影像学随访。临床结果采用欧洲足部和踝关节协会(EFAS)评分、足部功能指数(FFI)和曼彻斯特-牛津足部问卷(MOXFQ)进行评估。影像学评估按照 Maestro 标准进行。
与基线测量值相比,两组患者在临床和影像学结果方面均有所改善。前溃疡组和溃疡组在临床和影像学结果方面均无统计学差异,唯一的例外是 FFI,前溃疡组的 FFI 较低。多变量分析显示,性别和糖化血红蛋白(HbA)是预测结果更好的因素。具体来说,FFI 和 MOXFQ(<0.05)在女性中表现出更大的改善,而 Maestro 1 和 2 在 HbA 较低的患者中表现更好(<0.05)。所有患者在最终随访时均被认为已愈合。
精心实施的微创远端跖骨干骺端截骨术可以成为治疗即将发生或慢性足底糖尿病足溃疡的有效方法。