Schöbi Nina, Duppenthaler Andrea, Horn Matthias, Bartenstein Andreas, Keitel Kristina, Kopp Matthias V, Agyeman Philipp K A, Aebi Christoph
Division of Pediatric Infectious Disease, Department of Pediatrics, Bern University Hospital, Inselspital, University of Bern, CH-3010 Bern, Switzerland.
Department of Pediatric Surgery, Bern University Hospital, Inselspital, University of Bern, CH-3010 Bern, Switzerland.
Infect Dis Rep. 2024 Sep 2;16(5):864-869. doi: 10.3390/idr16050067.
A Europe-wide outbreak of invasive pediatric group A streptococcal infections (iGAS) began in fall 2022. Here, we report the evolution of GAS hospitalizations in children and adolescents during the second outbreak year in 2023-2024 at a tertiary center in Switzerland. Using prospective monitoring of all in-patient GAS cases below 16 years of age, including those with iGAS, we compared case frequencies and clinical characteristics in three time periods (2013-2020; 2022-2023; 2023-2024). Annual GAS hospitalizations increased from a median of 25 cases (range 11-28) in 2013-2020 to 89 and 63 cases, respectively, in 2022-2023 and 2023-2024. iGAS cases evolved similarly (2013-2020, 4 cases (3-8); 2022-2023, 32 cases; 2023-2024, 21 cases). The decline in cases from 2022-2023 to 2023-2024 included all types of GAS organ involvement, except suppurative infections in the head area, which remained largely unchanged (48 vs. 45 cases). Pleural empyema declined from 13 to 7 cases, possibly explained by a poor overlap of the GAS and influenza curves, respectively, in 2023-2024 compared to 2022-2023. These data document the prolongation of the GAS outbreak into its second winter season in 2023-2024.
2022年秋季，欧洲范围内爆发了侵袭性儿童A组链球菌感染（iGAS）疫情。在此，我们报告了2023 - 2024年瑞士一家三级医疗中心在第二次疫情爆发年度儿童和青少年A组链球菌住院情况的演变。通过对所有16岁以下住院A组链球菌病例（包括iGAS病例）进行前瞻性监测，我们比较了三个时间段（2013 - 2020年；2022 - 2023年；2023 - 2024年）的病例频率和临床特征。A组链球菌年度住院病例数从2013 - 2020年的中位数25例（范围11 - 28例）分别增至2022 - 2023年的89例和2023 - 2024年的63例。iGAS病例的变化情况类似（2013 - 2020年，4例（3 - 8例）；2022 - 2023年，32例；2023 - 2024年，21例）。从2022 - 2023年到2023 - 2024年病例数下降的情况涵盖了所有类型的A组链球菌器官受累情况，但头部区域的化脓性感染基本保持不变（分别为48例和45例）。胸腔积脓从13例降至7例，这可能是由于与2022 - 2023年相比，2023 - 2024年A组链球菌和流感曲线的重叠情况不佳所致。这些数据表明，A组链球菌疫情在2023 - 2024年持续到了第二个冬季。
